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CONGENER-DEPENDENT DISTRIBUTION AND EXCRETION: A COMPARISON OF BDES 47, 99, 100, AND 153 TOXICOKINETICS.
Citation:
STASKAL, D., D. BAUER, J. J. DILIBERTO, AND L. S. BIRNBAUM. CONGENER-DEPENDENT DISTRIBUTION AND EXCRETION: A COMPARISON OF BDES 47, 99, 100, AND 153 TOXICOKINETICS. Presented at BFR 2005, Baltimore, MD, June 03 - 06, 2005.
Description:
Polybrominated diphenyl ethers (PBDEs) represent a novel class of chemicals used as flame retardants predominantly in textiles, furniture, and electronics. Evidence demonstrating the bioaccumulation of these brominated flame retardants in humans has spurred research into potential deleterious health effects. Several BDE congeners have been shown to be endocrine disruptors, developmental reproductive and neurotoxicants. Of particular interest to the risks associated with these chemicals is the disassociation of congener profiles found in commercial mixtures with those found in the environment and human biota. This inconsistency is most likely due to differences in exposure as well as potential differences in toxicokinetics, underlying the need to understand the toxicokinetic parameters associated with each congener. In this study, the distribution and excretion of a single, i.v. dose of BDEs 47, 99, 100, and 153 are examined in female C57BL/6 mice. Five days following exposure, 40, 16, 6, and 2% of the BDE 47, 99, 100, and 153, respectively, were excreted in the urine. In the feces, 18-42% was excreted during the five day collection period. Tissue disposition of each congener was driven by its lipophilicity; fat and other lipophilic tissues were the primary depot for all congeners. BDE 153 demonstrated the greatest potential for bioaccumulation. The distribution patterns of these congeners are primarily driven by their chemical and physical properties; however, the excretion patterns appear to be dependent on the structure suggesting potential toxicokinetic differences may play a role in determining risks of each congener. (This abstract does not reflect EPA policy; this work partially supported by NHEERL-DESE CT826513 and NIEHS Service Award T32 ES07126.)