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TOXICOLOGICAL RESEARCH INVOLVING HUMANS: ETHICAL AND REGULATORY CONSIDERATIONS
Citation:
SCHWETZ, B. A., L. LEHMAN-MCKEEMAN, AND L. S. BIRNBAUM. TOXICOLOGICAL RESEARCH INVOLVING HUMANS: ETHICAL AND REGULATORY CONSIDERATIONS. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 85(1):419-421, (2005).
Impact/Purpose:
To present an argument to convince the Society of Toxicology to develop a policy for ethical research in humans.
Description:
This paper discusses the need for the Society of Toxicology (SOT) to develop a policy for ethical research in humans, and a review for publication of these studies. Observations on human beings have been the foundation upon which toxicologic knowledge has been built since the inception of toxicology as a science that developed information on cause-and-effect relationships between exposures to substances and subsequent undesired health effects. Observations by Sir Percival Pott and others in the 1700s were instrumental in creating an understanding between occupational exposures and cancer. In the 20th century, many sources of exposure from the workplace, foods, drugs, and environment were found to contribute to the human disease load based on observations on humans.