You are here:
DEVELOPMENT OF A BIOMARKERS DATABASE FOR THE NATIONAL CHILDREN'S STUDY, PROCEEDINGS TO BE PUBLISEHD FROM THE INTERNATIONAL CONFERENCE ON BIOMARKERS FOR TOXICOLOGY AND MOLECULAR EPIDEMIOLOGY, ATLANTA, GA, MARCH 15-17, 2004
Citation:
LOBDELL, D. T. AND P Mendola. DEVELOPMENT OF A BIOMARKERS DATABASE FOR THE NATIONAL CHILDREN'S STUDY, PROCEEDINGS TO BE PUBLISEHD FROM THE INTERNATIONAL CONFERENCE ON BIOMARKERS FOR TOXICOLOGY AND MOLECULAR EPIDEMIOLOGY, ATLANTA, GA, MARCH 15-17, 2004. TOXICOLOGY AND APPLIED PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 206(2):269-73, (2005).
Impact/Purpose:
To explore potential biomarkers that could be important measurements
Description:
The National Children's Study (NCS) is a federally-sponsored, longitudinal study of environmental influences on the health and development of children across the United States (www.nationalchildrensstudy.gov). Current plans are to study approximately 100,000 children and their families beginning before birth up to age 21 years.
To explore potential biomarkers that could be important measurements in the NCS, we compiled the relevant scientific literature to identify both routine or standardized biological markers as well as new and emerging biological markers. Although the search criteria encouraged examination of factors that influence the breadth of child health and development, attention was primarily focused on exposure, susceptibility and outcome biomarkers associated with four important child health outcomes: autism and neurobehavioral disorders, injury, cancer and asthma.
The Biomarkers Database was designed to allow users to: (1) search the biomarker records compiled by type of marker (susceptibility, exposure or effect), sampling media (e.g., blood, urine, etc.), and specific marker name; (2) search the citations file; and (3) read the abstract evaluations relative to our search criteria. A searchable, user-friendly database of over 2000 articles was created and is publicly available at: www.epa.gov/ncea/ncs. PubMed was the primary source of references with some additional searches of Toxline, NTIS, and other reference databases. Our initial focus was on review articles, beginning as early as 1996, supplemented with searches of the recent primary research literature from 2001- 2003. We anticipate this database will have applicability for the NCS as well as other studies of children's environmental health.
Key words: biomarkers, children, environmental health, database
Disclaimer
This information in this document has been funded in part by the US Environmental Protection Agency. It has been subjected to review by the National Health and Environmental Effects Research Laboratory and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.