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PROGRESS TOWARDS DEVELOPMENT OF AN AMPHIBIAN-BASED THYROID SCREENING ASSAY USING XENOPUS LAEVIS: ORGANISMAL AND THYROIDAL RESPONSES TO THE MODEL COMPOUNDS 6-PROPYLTHIOURACIL, METHIMAZOLE, AND THYROXINE.
Citation:
Degitz, S J., G W. Holcombe, K. M. Flynn, P A. Kosian, J J. Korte, AND J E. Tietge. PROGRESS TOWARDS DEVELOPMENT OF AN AMPHIBIAN-BASED THYROID SCREENING ASSAY USING XENOPUS LAEVIS: ORGANISMAL AND THYROIDAL RESPONSES TO THE MODEL COMPOUNDS 6-PROPYLTHIOURACIL, METHIMAZOLE, AND THYROXINE. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 87(2):353-364, (2005).
Impact/Purpose:
To address the development and standardization needs associated with an amphibian thyroid axis screening assay
Description:
The data presented in this manuscript specifically addresses the development and standardization needs associated with an amphibian thyroid axis screening assay. A protocol for an amphibian growth and reproduction test has been requested by the Office of Science Council and Policy (OSCP) within the Office of Pesticides, Prevention and Toxic Substances, the program office charged with implementation of an EDC screening program for EPA. A variation of the protocol has been proposed as a test methd in support of an effort by the Organization for Economic Cooperation and Development (OECD) to develop assays for internationally-harmonized EDC testing.