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DEVELOPMENTAL DISRUPTION OF THYROID HORMONE: CORRELATIONS WITH HEARING DYSFUNCTION IN RATS.
Citation:
Crofton, K M. DEVELOPMENTAL DISRUPTION OF THYROID HORMONE: CORRELATIONS WITH HEARING DYSFUNCTION IN RATS. RISK ANALYSIS. Society For Risk Analysis, 24:1665-1671, (2004).
Impact/Purpose:
to develop better biomarkers of effect
Description:
A manuscript presents evidence that thyroxine (T4) is a good biomarker-of-effect for developmental neurotoxicity associated with exposure to environmental thyrotoxicants. A major uncertainty in assessing the risks of developmental exposure to thyrotoxicants is the lack of a clear characterization of the dose-response relationship, especially in the lower region, between disruption of hormones and adverse consequences. The current work correlated early postnatal hypothyroxinemia with hearing loss in the adult rat. Analyses revealed a highly significant linear correlation between T4 concentration and hearing loss. This correlation demonstrates that T4 is a good predictive biomarker in rodents of the adverse neurological consequences of developmental exposure to thyrotoxicants.