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MICROWAVE-ASSISTED CU (I) CATALYZED SOLVENT-FREE THREE COMPONENT COUPLING OF ALDEHYDE, ALKYNE AND AMINE
Citation:
Ju**,Y., C. J. Li, AND R S. Varma*. MICROWAVE-ASSISTED CU (I) CATALYZED SOLVENT-FREE THREE COMPONENT COUPLING OF ALDEHYDE, ALKYNE AND AMINE. C. O. Kappe (ed.), QSAR & COMBINATORIAL SCIENCE. Wiley-VCH, Weinheim, Germany, 23(10):891-894, (2004).
Description:
Direct Grignard type addition of terminal alkynes to in situ generated imines, from aldehydes and amines, occurs under microwave irradiation using CuBr alone in a one-pot operation. This solventless approach provides ready access to propargylamines and is applicable both to aromatic and aliphatic aldehydes.
Record Details:
Record Type:DOCUMENT( JOURNAL/ PEER REVIEWED JOURNAL)
Product Published Date:12/30/2004
Record Last Revised:03/10/2006
OMB Category:Other
Record ID:
104721