You are here:
RELATIONAHIP BETWEEN AMBIENT AIR QUALITY AND SELECTED BIRTH DEFECTS, SEVEN COUNTY STUDY, TEXAS, 1997-2000
Citation:
Gilboa, S., P Mendola, Olshan. AF, D. A. Savitz, D. Loomis, A. H. Herring, AND D. Fixler. RELATIONAHIP BETWEEN AMBIENT AIR QUALITY AND SELECTED BIRTH DEFECTS, SEVEN COUNTY STUDY, TEXAS, 1997-2000. AMERICAN JOURNAL OF EPIDEMIOLOGY. Johns Hopkins Bloomberg School of Public Health, 162(3):238-52, (2005).
Impact/Purpose:
to examine the relationship between ambient air quality and birth defects
Description:
A population-based case-control study investigated the association between maternal exposure to criteria air pollutants, CO, NO2, O3, SO2, and PM10 during weeks three through eight of pregnancy, and the risk of selected cardiac birth defects and oral clefts among live births and fetal deaths between 1997 and 2000 in seven Texas counties. Controls were frequency matched to cases on year of birth, vital status and maternal county of residence at delivery. Stationary air monitoring data was used to estimate air pollution exposure. Logistic regression models were used to adjust for covariates available in the vital record. Comparing the highest quartile of exposure to the lowest, we observed positive associations between CO and tetralogy of fallot (odds ratio (OR) = 2.04; 95% confidence interval (CI) 1.26, 3.29), PM10 and isolated atrial septal defect (OR = 2.27; 95% CI: 1.43, 3.60), and SO2 and isolated ventricular septal defect (OR = 2.16; 95% CI: 1.51, 3.09) and inverse associations between NO2 and ventricular septal defect (OR = 0.76; 95% CI: 0.64, 0.91) and SO2 and isolated atrial septal defect (OR = 0.42; 95% CI: 0.22, 0.78). An association between ozone and pulmonary artery and valve defects reported previously was confirmed.