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NICOTINE EFFECTS ON THE ACTIVITY OF MICE EXPOSED PRENATALLY TO THE NICOTINIC AGONIST ANATOXIN-A.
Citation:
MacPhail, R C., J D. Farmer, K A. Jarema, AND N Chernoff. NICOTINE EFFECTS ON THE ACTIVITY OF MICE EXPOSED PRENATALLY TO THE NICOTINIC AGONIST ANATOXIN-A. NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Online, New York, NY, 27:593-598, (2005).
Impact/Purpose:
To evaluate the motor activity of adult mice, and their response to nicotine, that have been exposed prenatally to a potent nicotinic agonist
Description:
Considerable research has shown long-lasting effects of early exposure in experimental animals to nicotine. Anatoxin-a is produced by cyanobacteria and has been shown to be a potent nicotinic agonist. This experiment evaluated the motor activity of adult mice, and their response to nicotine, that had been exposed prenatally to anatoxin-a. Results showed that under our conditions prenatal anatoxin-a exposure did not alter the motor activity of adult mice or the effects of a nicotine challenge dose on their activity.