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BINDING OF CARCINOGENS TO DNA AND COVALENT ADDUCTS DNA DAMAGE - PAH, AROMATIC AMINES, NITRO-AROMATIC COMPOUNDS, AND HALOGENATED COMPOUNDS
Citation:
Ross, J A. BINDING OF CARCINOGENS TO DNA AND COVALENT ADDUCTS DNA DAMAGE - PAH, AROMATIC AMINES, NITRO-AROMATIC COMPOUNDS, AND HALOGENATED COMPOUNDS. Chapter 4, Molecular Carcinogenesis and the Molecular Biology of Human Cancer. CRC Press - Taylor & Francis Group, LLC, Boca Raton, FL, , 79-101, (2006).
Impact/Purpose:
To discuss the context for a central role of DNA adducts in the process of genotoxic carcinogenesis
Description:
DNA adducts are the covalent addition products resulting from binding of reactive chemical species to DNA bases. The cancer initiating role of DNA adducts is well-established, and is clearly reflected in the high cancer incidence observed in individuals with deficiencies in any of a variety of DNA repair enzymes . As early as the mid 1960s, researchers in chemical carcinogenesis were reaching the consensus that there was a strong relationship between the extent of binding of carcinogens or their metabolites to DNA and their carcinogenic potency. Research interest in DNA adducts derives from the central role of DNA damage in inducing heritable changes in DNA structure that can lead to a variety of adverse health effects. Figure 1 illustrates the context for a central role of DNA adducts in the process of genotoxic carcinogenesis.