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An Update on the SeqAPASS Tool
Citation:
LaLone, C. An Update on the SeqAPASS Tool. U.S. Environmental Protection Agency – Japan Ministry of the Environment, 14th Bilateral Meeting on Endocrine Disruption Test Methods Development, Duluth, MN, June 09, 2021. https://doi.org/10.23645/epacomptox.14721162
Impact/Purpose:
The US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS; https://seqapass.epa.gov/seqapass/) v5.0 tool allows users to compare protein similarity across species. This is important because chemicals act on protein targets. Therefore, by understanding how similar proteins are across species, the SeqAPASS tool can produce chemical susceptibility predictions across hundreds of species rapidly. New features have been integrated in the newest release of SeqAPASS that assist with data interpretation, including a heat map visualization of individual amino acid comparisons. Additional features allow for the generation of user customized data reports for ease of interpretation and synthesis across the different levels of the SeqAPASS evaluation. The Additional features are intended to assist users of the SeqAPASS tools in extrapolating toxicity knowledge across species rapidly and transparently.
Description:
Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS), is a fast, online screening tool that allows researchers and regulators to extrapolate toxicity information across species. For some species, such as humans, mice, rats, and zebrafish, the EPA has a large amount of data regarding their toxicological susceptibility to various chemicals. SeqAPASS extrapolates from these data rich model organisms to thousands of other non-target species to evaluate their specific potential chemical susceptibility. SeqAPASS Version 5.0 adds several new features including a customizable heat map for individual amino acid comparisons that allows for more rapid interpretation and use of the data for publication and presentation quality graphics. The new update also allows users to synthesize SeqAPASS results (i.e., data tables and visualizations) across all Levels (1, 2, and 3) of the SeqAPASS evaluation using a customizable Decision Summary Report. This report can be exported as a pdf. The contents of this abstract neither constitute nor necessarily reflect US EPA policy.
URLs/Downloads:
DOI: An Update on the SeqAPASS Tool
2021_JAPAN-US BILATERAL SEQAPASS.PPT.PDF (PDF, NA pp, 3721.368 KB, about PDF)