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PEROXISOME-PROLIFERATOR ACTIVATED RECEPTORS AS A MACROMOLECULAR TARGET FOR CHEMICAL TOXICITY: MODELS OF THE INTERACTIONS OF PPARS WITH PERFLUORINATED ORGANIC COMPOUNDS.
Citation:
GOLDSMITH, M. AND J. R. RABINOWITZ. PEROXISOME-PROLIFERATOR ACTIVATED RECEPTORS AS A MACROMOLECULAR TARGET FOR CHEMICAL TOXICITY: MODELS OF THE INTERACTIONS OF PPARS WITH PERFLUORINATED ORGANIC COMPOUNDS. Presented at BOARD OF SCIENTIFIC COUNSELORS (BOSC), RTP, NC, June 19 - 20, 2006.
Impact/Purpose:
The Peroxisome Proliferator Activated Receptors (PPARs), a class of nuclear receptors that modulate both transcription and metabolic processes, are implicated in a variety of metabolic disorders linked to lipidogenesis, adipose tissue accumulation, fatty-acid oxidation pathways, Type-II diabetes and metabolic syndrome. Many toxicological processes may be studied using the same paradigmsas used in this study. As a result, methods applied here may have a far reaching effect for evaluating the risk of this and other classes of chemicals and other macromolecular targets
Description:
The Peroxisome Proliferator Activated Receptors (PPARs), a class of nuclear receptors that modulate both transcription and metabolic processes, are implicated in a variety of metabolic disorders linked to lipidogenesis, adipose tissue accumulation, fatty-acid oxidation pathways, Type-II diabetes and metabolic syndrome. Many toxicological processes may be studied using the same paradigmsas used in this study. As a result, methods applied here may have a far reaching effect for evaluating the risk of this and other classes of chemicals and other macromolecular targets