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GENOTOXICITY STUDIES OF SODIUM DICHLOROACETATE AND SODIUM TRICHLOROACETATE
Citation:
Meier, J., B. E. Stewart, AND W. F. Blazak. GENOTOXICITY STUDIES OF SODIUM DICHLOROACETATE AND SODIUM TRICHLOROACETATE. Environmental Sciences 5(2):095-108, (1997).
Description:
The genotoxic properties of sodium dichloroacetate (DCA) and sodium trichloroacetate (TCA)were evaluated in several short-term in vitro and in vivo assays. Neither compound was mutagenic in tester strain TA102 in the Salmonella mutagenicity assay. Both DCA and TCA were weak inducers of sister chromatid exchanges in Chinese hamster ovary cells in vitro. TCA was more acutely toxic than DCA both in vitro and in vivo. DCA induced high levels of sperm-head abnormalities in mice in vivo, and led to decreased sperm counts on exposure of late spermatogonial stage cells, whereas TCA did not influence any of the sperm parameters examined. Neither compound induced the formation of micronucleated polychromatic erythrocytes in bone marrow of mice.