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IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft)
Citation:
U.S. EPA. IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-11/081C, 2011.
Impact/Purpose:
EPA is undertaking an Integrated Risk Information System (IRIS) health assessment for n-butanol. IRIS is an EPA database containing Agency scientific positions on potential adverse human health effects that may result from chronic (or lifetime) exposure to chemicals in the environment. IRIS contains chemical-specific summaries of qualitative and quantitative health information in support of two steps of the risk assessment paradigm, i.e., hazard identification and dose-response evaluation. IRIS assessments are used in combination with specific situational exposure assessment information to evaluate potential public health risk associated with environmental contaminants.
Description:
On September 8, 2011, the Toxicological Review of n-Butanol (External Review Draft) was released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Offices before public release. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments with EPA's response and the interagency science consultation draft of the IRIS Toxicological Review of n-Butanol and the charge to external peer reviewers are posted on this site.
URLs/Downloads:
IRIS Toxicological Review of n-Butanol (Interagency Science Consultation Draft) (PDF, 136 pp, 1001 KB, about PDF)Charge to External Peer Reviewers (PDF, 2 pp, 29 KB, about PDF)
EPA's Response and Comments from the Interagency Science Consultation (PDF, 12 pp, 85 KB, about PDF)