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A Systems Approach to Exposure Modeling (ExpoCast)(FutureTox3)
Citation:
Wambaugh, J. A Systems Approach to Exposure Modeling (ExpoCast)(FutureTox3). Presented at SOT FutureTox III, Arlington, VA, November 19 - 20, 2015. https://doi.org/10.23645/epacomptox.5067691
Impact/Purpose:
This presentation provides a broad overview of ongoing research activities in the CSS Rapid Exposure and Dosimetry task. The meeting FutureTox III: Bridges for Translation is being held in Arlington, Virginia and is sponsored by the Society for Toxicology.
Description:
Systems Biology might be described as the understanding of how interactions on multiple scales integrate into a homeostatic system. Systems Toxicology could then be the study of the impact of chemical perturbations of homeostasis. Systems exposure might then be the study of the interactions between chemicals and the many pathways that convey those chemicals to biological receptors (human and ecological. These pathways convey thousands of existing and emerging commercial chemicals through environmental media, consumer products, and articles of commerce. The timely characterization of the human and ecological risk posed by these chemicals is a critical challenge facing the US EPA. High throughput screening (HTS) data characterizing chemical-induced biological activity has been generated for thousands of environmentally-relevant chemicals by the US inter-agency Tox21 and the US EPA ToxCast programs. For a limited set of chemicals, bioactive concentrations related to over 800 diverse assay endpoints can be directly integrated with ongoing exposure biomonitoring programs, such as the blood and serum chemical concentration datasets generated by the US Centers for Disease Control National Health and Nutrition Survey. In most cases, however, the data needed to compare bioactivity from HTS with relevant human exposures does not exist. The EPA’s ExpoCast program is developing high throughput approaches to generate exposure estimates using existing databases and new, high throughput measurements including physico-chemical properties, concentrations in consumer products, and non-targeted monitoring for occurrence in environmental and biological samples. Derived from a systems understanding of exposure pathways, these exposure estimates are critical in developing rapid and cost-effective testing priorities for thousands of chemicals that currently lack hazard and exposure data. This abstract does not necessarily reflect U.S. EPA policy.
URLs/Downloads:
DOI: A Systems Approach to Exposure Modeling (ExpoCast)(FutureTox3)
FUTURETOX3-2015-WAMBAUGH_PRESENTATION.PDF (PDF, NA pp, 1105.504 KB, about PDF)