EPA Science Inventory

BIRTH DEFECTS RISK ASSOCIATED WITH MATERNAL SPORT FISH CONSUMPTION: POTENTIAL EFFECT MODIFICATION BY SEX OF OFFSPRING

Citation:

Mendola, P, L. K. Robinson, G. M. Buck, E. Fitzgerald, C. M. Druschel, L. E. Sever, AND J. E. Vena. BIRTH DEFECTS RISK ASSOCIATED WITH MATERNAL SPORT FISH CONSUMPTION: POTENTIAL EFFECT MODIFICATION BY SEX OF OFFSPRING. ENVIRONMENTAL RESEARCH. Elsevier Science BV, Amsterdam, Netherlands, 97(2):133-140, (2005).

Description:

Contaminated sport fish consumption may result in exposure to various reproductive and developmental toxicants, including pesticides and other suspected endocrine disruptors. We investigated the relation between maternal sport fish meals and risk of major birth defects among infants born to members of the New York State (NYS) Angler Cohort between 1986 and 1991 ( [Formula: see text] births). Birth defects ( [Formula: see text] cases) were ascertained from both newborn medical records and the NYS Congenital Malformations Registry. For sport fish meals eaten during pregnancy, the odds ratio (OR) for all major malformations combined was slightly elevated for 1 meal/month (OR=1.26, 95% confidence interval (CI): 0.84, 1.89) and 2 meals/month (OR=1.51, CI=0.74, 3.09), with no meals during pregnancy as the reference category. Higher ORs were consistently observed among male offspring compared with females. For 2 meals/month, the risk for males was significantly elevated (males: OR=3.01, CI: 1.2, 7.5; females: OR=0.73, CI: 0.2, 2.4). Exposure during pregnancy and effect modification by infants sex could be important considerations for future studies of birth outcomes associated with endocrine disruptors.

Purpose/Objective:

To investigate the relation between maternal sport fish meals and risk of major birth defects

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 02/01/2005
Completion Date: 02/01/2005
Record Last Revised: 07/14/2008
Record Created: 11/19/2004
Record Released: 11/19/2004
OMB Category: Other
Record ID: 89775

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

HUMAN STUDIES DIVISION

EPIDEMIOLOGY AND BIOMARKERS BRANCH