EPA Science Inventory

The Environment-Immune Route to Chronic Disease

Citation:

Dietert, R. R. AND R. W. LUEBKE. The Environment-Immune Route to Chronic Disease. Chapter 2, R. Dietert and R. Luebke (ed.), Immunotoxicity, Immune Dysfunction and Chronic Disease. Springer, New York, NY, Part 1:31-47, (2012).

Description:

Specific environmental factors including chemicals, drugs, microbes and both physical and psychological factors can affect the immune system producing dysfunction and, ultimately, an increased risk ofchronic disease. Several different types of immune alterations can result from environmentally-induced immunotoxicity, and these connect immune insult to chronic disease. We illustrate how many immune-based chronic diseases arising in non-lymphoid tissues may be categorized based on the target tissue (e.g., skin, lung) rather than on the probable cause: a dysfunctional immune system. Finally, we discuss various factors that affect: 1) susceptibility to immunotoxicity and 2) the specific spectrum of disease outcomes following exposure.

Purpose/Objective:

Specific environmental factors including chemicals, drugs, microbes and both physical and psychological factors can affect the immune system producing dysfunction and, ultimately, an increased risk of chronic disease. Several different types of immune alterations can result from environmentally-induced immunotoxicity, and these connect immune insult to chronic disease. We illustrate how many immune-based chronic diseases arising in non-lymphoid tissues may be categorized based on the target tissue (e.g., skin, lung) rather than on the probable cause: a dysfunctional immune system. Finally, we discuss various factors that affect: I) susceptibility to immunotoxicity and 2) the specific spectrum of isease outcomes following exposure

URLs/Downloads:

IMMUNOTOXICITY, IMMUNE DYSFUNCTION AND CHRONIC DISEASE   Exit

Record Details:

Record Type: DOCUMENT (BOOK CHAPTER)
Start Date: 08/01/2012
Completion Date: 08/01/2012
Record Last Revised: 04/16/2014
Record Created: 12/29/2011
Record Released: 12/29/2011
OMB Category: Other
Record ID: 240284

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

ENVIRONMENTAL PUBLIC HEALTH DIVISION

CARDIOPULMONARY AND IMMUNOTOXICOLOGY BRANCH