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Inhibition of the Thyroid Hormone Pathway in Xenopus laevis by 2-mercaptobenzothiazole
TIETGE, J. E., S. J. DEGITZ, J. HASELMAN, B. C. BUTTERWORTH, J. J. KORTE, P. A. KOSIAN, A. LINDBERG-LIVINGSTON, E. M. BURGESS, P. BLACKSHEAR, AND M. HORNUNG. Inhibition of the Thyroid Hormone Pathway in Xenopus laevis by 2-mercaptobenzothiazole. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 126:128-136, (2012).
Modernizing the battery of EDSP Tier I tests is not only desirable, but it is inevitable. Advances in science over the past decade have enabled such modernization to occur. The studies presented here establish the groundwork for the Agency to move toward modernization of the AMA, resulting in an assay with shorter duration yet higher diagnostic specificity with regard to thyroid toxicants. In addition, by incorporating in vitro screening for TPO inhibition, a method to prioritize chemicals for Tier I testing appears to be a viable approach to focus testing resources on those chemicals which are shown to have activity related to a specific mode of thyroid disruption.
To document research results.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
MID-CONTINENT ECOLOGY DIVISION
TOXIC EFFECTS CHARACTERIZATION RESEARCH