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Inhibition of the Thyroid Hormone Pathway in Xenopus laevis by 2-mercaptobenzothiazole
Citation:
TIETGE, J. E., S. J. DEGITZ, J. HASELMAN, B. C. BUTTERWORTH, J. J. KORTE, P. A. KOSIAN, A. LINDBERG-LIVINGSTON, E. M. BURGESS, P. BLACKSHEAR, AND M. HORNUNG. Inhibition of the Thyroid Hormone Pathway in Xenopus laevis by 2-mercaptobenzothiazole. AQUATIC TOXICOLOGY. Elsevier Science Ltd, New York, NY, 126:128-136, (2012).
Impact/Purpose:
To document research results.
Description:
Modernizing the battery of EDSP Tier I tests is not only desirable, but it is inevitable. Advances in science over the past decade have enabled such modernization to occur. The studies presented here establish the groundwork for the Agency to move toward modernization of the AMA, resulting in an assay with shorter duration yet higher diagnostic specificity with regard to thyroid toxicants. In addition, by incorporating in vitro screening for TPO inhibition, a method to prioritize chemicals for Tier I testing appears to be a viable approach to focus testing resources on those chemicals which are shown to have activity related to a specific mode of thyroid disruption.
