EPA Science Inventory

Behavioral changes in adult and young rats as indications of cholinesterase inhibition

Citation:

MOSER, V. C. Behavioral changes in adult and young rats as indications of cholinesterase inhibition. Chapter 11, (Knaak JB, Timchalk C, Tornero-Velez R, ed) (ed.), American Chemical Society Symposium Series: Parameters for pesticide QSAR and PBPK/PD Models for Human risk assessment. American Chemical Society, Washington, DC, 1099:167-68, (2012).

Description:

Inhibition of acetylcholinesterase has long been accepted as the basis for neurotoxicity produced by organophosphorus (OP) and N-methyl carbamate chemicals. Functional or behavioral alterations result from acute exposure to these chemicals. We have evaluated behavioral changes and concurrent acetylcholinesterase inhibition in both adult and preweanling rats for a number of OPs and carbamates. A within-subject design allows direct correlations between these variables. Overall we have shown that there are different patterns of correlation between behavior and brain acetylcholinesterase inhibition, and these differ by endpoint and chemical. Furthermore, these correlations are different between adult and young animals. Chemical-specific data may therefore be necessary to inform neurotoxicity predictions from OP and carbamate PBPKJPD models. The data presented here were presented at the 2420d National Meeting of the American Chemical Society, August 2011. The views expressed in this paper are those of the author and do not necessarily reflect the views or policies ofthe U.S. Environmental Protection Agency.

Purpose/Objective:

We have evaluated behavioral changes and concurrent acetylcholinesterase inhibition in both adult and preweanling rats for a number of OPs and carbamates.

URLs/Downloads:

Record Details:

Record Type: DOCUMENT (BOOK CHAPTER)
Start Date: 07/01/2012
Completion Date: 07/01/2012
Record Last Revised: 01/24/2013
Record Created: 10/08/2011
Record Released: 10/08/2011
OMB Category: Other
Record ID: 238806

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

TOXICOLOGY ASSESSMENT DIVISION

NEUROTOXICOLOGY BRANCH