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Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling
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Citation:
RODRIGUEZ, C. E., D. A. Mahle, J. M. Gearhart, D. R. Mattie, J. C. LIPSCOMB, R. S. Cook, AND H. A. BARTON. Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling. TOXICOLOGICAL SCIENCES. Society of Toxicology, 98(1):43-56, (2007).Description:
The capability of physiologically based pharmacokinetic models to incorporate age-appropriate physiological and chemical-specific parameters was utilized to predict changes in internal dosimetry for six volatile organic compounds (VOCs) across different ages of rats.
Purpose/Objective:
The capability of physiologically based pharmacokinetic models to incorporate age-appropriate physiological and chemical-specific parameters was utilized to predict changes in internal dosimetry for six volatile organic compounds (VOCs) across different ages of rats.
Record Details:
Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)Start Date: 04/10/2007
Completion Date: 04/10/2007
Record Last Revised: 03/19/2009
Record Created: 11/10/2007
Record Released: 11/10/2007
OMB Category: Other
Record ID: 186824
Organization:
U.S. ENVIRONMENTAL PROTECTION AGENCYOFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY
IMMEDIATE OFFICE