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EXTRAHEPATIC METABOLISM IN CYP2E1 IN PBPK MODELING OF LIPOPHILIC VOLATILE ORGANIC CHEMICALS: IMPACTS ON METABOLIC PARAMETER ESTIMATION AND PREDICTION OF DOSE METRICS.

Contact

phone: 9195411995

email: barton.hugh@epa.gov

Citation:

YOON, M., M. C. MADDEN, AND H. A. BARTON. EXTRAHEPATIC METABOLISM IN CYP2E1 IN PBPK MODELING OF LIPOPHILIC VOLATILE ORGANIC CHEMICALS: IMPACTS ON METABOLIC PARAMETER ESTIMATION AND PREDICTION OF DOSE METRICS. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH. Taylor & Francis, Inc., Philadelphia, PA, 7(18):1527-1541, (2007).

Description:

Physiologically based pharmacokinetic (PBPK) models increasingly are available for environmental chemicals and applied in risk assessments.

Purpose/Objective:

Physiologically based pharmacokinetic (PBPK) models increasingly are available for environmental chemicals and applied in risk assessments.

URLs/Downloads:

EXTRAHEPATIC METABOLISM IN CYP2E1 IN PBPK MODELING OF LIPOPHILIC VOLATILE ORGANIC CHEMICALS: IMPACTS ON METABOLIC PARAMETER ESTIMATION AND PREDICTION OF DOSE METRICS. Exit EPA's Web Site

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)

Start Date: 09/01/2007

Completion Date: 09/01/2007

Record Last Revised: 12/03/2008

Record Created: 01/10/2007

Record Released: 01/10/2007

OMB Category: Other

Record ID: 162549

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY
IMMEDIATE OFFICE

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