EPA Science Inventory

MINI REVIEW - EPIGENETIC PROCESSES AND CANCER RISK ASSESSMENT

Citation:

PRESTON, R J. MINI REVIEW - EPIGENETIC PROCESSES AND CANCER RISK ASSESSMENT. MUTATION RESEARCH - FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. Elsevier Science Ltd, New York, NY, 616(1-2):7-10, (2007).

Description:

Abstract: The U.S. Environmental Protection Agency's Guidelines for Carcinogen Risk Assessment encourages the use of mechanistic data in the assessment of human cancer risk at low (environmental) exposure levels. The key events that define a particular mode of action for tumor formation have been concentrated to date more on mutational responses that are broadly the result of induced DNA damage and enhanced cell proliferation. While it is clear that these processes are important in terms of humor induction, other modes that fall under the umbrella of epigenetic responses are increasingly being considered to play an important role in susceptibility to tumor induction by environmental chemicals and as significant modifiers of tumor responses. Alterations in gene expression, DNA repair, cell cycle control, genome stability and genome reprogramming could be the result of modification of DNA methylation and chromatin remodeling patterns as a consequence of exposure to environmental chemicals. These concepts are described and discussed.

Purpose/Objective:

To evaluate epigenetic processes in the context of cancer risk assessment.

URLs/Downloads:

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 03/01/2007
Completion Date: 12/31/2007
Record Last Revised: 06/21/2007
Record Created: 06/01/2006
Record Released: 06/01/2006
OMB Category: Other
Record ID: 154645

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

ASSOCIATE DIRECTOR FOR HEALTH

IMMEDIATE OFFICE