EPA Science Inventory

COMMONALITIES IN METABOLISM OF ARSENICALS

Citation:

ADAIR, B., S. B. WATERS, V. DEVESA I PEREZ, Z. DROBNA, M. STYBLO, AND D. J. THOMAS. COMMONALITIES IN METABOLISM OF ARSENICALS. ENVIRONMENTAL CHEMISTRY. CSIRO Publishing, Collingwood Victoria, Australia, 2:161-166, (2005).

Description:

Elucidating the pathway of inorganic arsenic metabolism shows that some of methylated arsenicals formed as intermediates and products are reactive and toxic species. Hence, methylated arsenicals likely mediate at least some of the toxic and carcinogenic effects associated with exposure to arsenic. Trimethylarsonium compounds and arsenosugars are two other classes of arsenicals to which humans are routinely exposed and there is evidence that both classes are metabolized to produce methylated arsenicals. Here, we review evidence for production of methylated metabolism and consider the challenges posed in unraveling a complex web for metabolism of arsenicals in humans.

Purpose/Objective:

To review evidence for production of methylated metabolism of arsenicals

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 08/19/2005
Completion Date: 08/19/2005
Record Last Revised: 07/21/2006
Record Created: 10/05/2005
Record Released: 10/05/2005
OMB Category: Other
Record ID: 140833

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

EXPERIMENTAL TOXICOLOGY DIVISION

PHARMACOKINETICS BRANCH