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COMMONALITIES IN METABOLISM OF ARSENICALS
ADAIR, B., S. B. WATERS, V. DEVESA I PEREZ, Z. DROBNA, M. STYBLO, AND D. J. THOMAS. COMMONALITIES IN METABOLISM OF ARSENICALS. ENVIRONMENTAL CHEMISTRY. CSIRO Publishing, Collingwood Victoria, Australia, 2:161-166, (2005).
Elucidating the pathway of inorganic arsenic metabolism shows that some of methylated arsenicals formed as intermediates and products are reactive and toxic species. Hence, methylated arsenicals likely mediate at least some of the toxic and carcinogenic effects associated with exposure to arsenic. Trimethylarsonium compounds and arsenosugars are two other classes of arsenicals to which humans are routinely exposed and there is evidence that both classes are metabolized to produce methylated arsenicals. Here, we review evidence for production of methylated metabolism and consider the challenges posed in unraveling a complex web for metabolism of arsenicals in humans.
To review evidence for production of methylated metabolism of arsenicals
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
EXPERIMENTAL TOXICOLOGY DIVISION