EPA Science Inventory

INTERIM REPORT, DEVELOP A SAMPLING STRATEGY: PREPARE TO IMPLEMENT A COHORT STUDY OF CHILDREN'S ENVIRONMENTAL HEALTH

Citation:

MENDOLA, P. AND S. MYERS. INTERIM REPORT, DEVELOP A SAMPLING STRATEGY: PREPARE TO IMPLEMENT A COHORT STUDY OF CHILDREN'S ENVIRONMENTAL HEALTH. U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-05/017, 2005.

Description:

Overview

The goal of the National Children's Study (NCS) is to collect information on environmental and

social factors in the lives of children, starting before birth and continuing until age 21, to inform

researchers about their effects on the health and development of children. In this document, we propose

sample design options to be considered for implementation in a North Carolina-based longitudinal cohort

study (LCS). The purpose of the report is to present 'within-primary sampling unit (PSU)' procedures

for sampling, recruiting and collecting data for that 5,000-children cohort. EPA proposed in the work

assignment that initiated this work that RTI consider the sampling and design approaches currently under

consideration for the NCS, and develop sampling scheme options for the North Carolina-based pilot

study. Considerable work has already been done for the NCS by Battelle (Strauss et al, 2004) and Westat

(Westat, 2002) in developing sampling scheme options. This report builds on the sample design options

already proposed and focuses on the possible implementation of the sample design schemes in North

Carolina counties.

The first-stage sample design for the NCS involves the selection of PSUs in the U.S. in which the

study will be conducted. The goal of the within-PSU sample selection is to obtain approximately 25% of

the children for the study from women who are at a pre-conception stage and the remaining 75% of the

children from women who are pregnant at recruitment, ideally in their first trimester. Two sample

designs are evaluated as possible options for the within-PSU sample selection using a probability-based

sampling scheme. The first option is based entirely on an area household sampling frame, as requested by

the WAM. The second option is a dual frame design that has the potential to provide equivalent

inferential support at reduced cost by incorporating area household sampling as well as sampling in the

offices of prenatal care providers. The dual frame design was initially proposed in the Work Plan as

RTI's main sampling strategy, and this approach had already been developed when we received feedback

from the WAM. Thus, it is included here for consideration.

Purpose/Objective:

We propose sample design options to be considered for implementation in a North Carolina-based longitudinal cohort study

URLs/Downloads:

Record Details:

Record Type: DOCUMENT (PUBLISHED REPORT/REPORT)
Start Date: 03/05/3005
Completion Date: 03/05/3005
Record Last Revised: 03/24/2015
Record Created: 01/27/2005
Record Released: 01/27/2005
OMB Category: Other
Record ID: 114978

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

HUMAN STUDIES DIVISION

EPIDEMIOLOGY AND BIOMARKERS BRANCH