EPA Science Inventory

A DATABASE FOR TRACKING TOXICOGENOMIC SAMPLES AND PROCEDURES

Citation:

Bao, W, J E. Schmid, A K. Goetz, H Ren, AND D J. Dix. A DATABASE FOR TRACKING TOXICOGENOMIC SAMPLES AND PROCEDURES. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 19(3):411-419, (2005).

Description:

Reproductive toxicogenomic studies generate large amounts of toxicological and genomic data. On the toxicology side, a substantial quantity of data accumulates from conventional endpoints such as histology, reproductive physiology and biochemistry. The largest source of genomics data is DNA microarrays, which generate enormous amounts of information in the course of profiling gene expression. Thus, data storage and management become essential and require a more sophisticated system than lab notebooks and electronic spreadsheets. We developed a toxicogenomics tracking database (TTD) for our reproductive studies based on the MIAME-Tox guidelines and relational database theory. This database stores the various types of data from both toxicological and genomic assays in a hierarchical fashion. The user-friendly interface provides easy procedures for researchers to add, edit, save, delete, and navigate different records. TTD also makes it practical to systematically export microarray data into public databases.

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Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 12/08/2004
Completion Date: 12/08/2004
Record Last Revised: 12/22/2005
Record Created: 12/08/2004
Record Released: 12/08/2004
Record ID: 111742

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

REPRODUCTIVE TOXICOLOGY DIVISION

GAMETE AND EARLY EMBRYO BIOLOGY BRANCH