EPA Science Inventory

CARDIOVASCULAR RESPONSES IN UNRESTRAINED WKY-RATS TO INHALED ULTRAFINE CARBON PARTICLES

Citation:

Harder, V., B. Lentner, E. Karg, S. Takenaka, A. Ziesenis, A. Stampfl, J. Heyder, H. Schulz, U P. Kodavanti, AND P. S. Gilmour. CARDIOVASCULAR RESPONSES IN UNRESTRAINED WKY-RATS TO INHALED ULTRAFINE CARBON PARTICLES. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 17(1):29-42, (2005).

Description:

Abstract
This study provides evidence for adverse cardiac effects of inhaled ultrafine particles (UFPs) in healthy WKY rats. Short term exposure (24 h) with carbon UFPs (180 ?g?m ?) induced a moderate but significant heart rate increase of 18 bpm (4.8 %) in association with a significant heart rate variability (HRV) decrease during particle inhalation. HRV analysis points to UFP induced alterations in cardiac autonomic balance, which seem to be mediated by a sympathetic stress response. After 24 h UFP exposure bronchoalveolar lavage revealed a significant low-grade pulmonary inflammation (clean air: 1.9 % vs. UFPs: 6.9 % PMNs) associated with sporadic accumulation of particle laden macrophages in the alveolar region. Regarding possible inflammation mediated increases in blood coagulability, UFP inhalation induced no significant prothrombotic changes on the protein and mRNA level. Histological analysis revealed no signs of cardiac inflammation or cardiomyopathic changes after short-term carbon UFP inhalation (4 h, 24 h).

Purpose/Objective:

To provide evidence for adverse cardiac effects of inhaled ultrafine particles

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 01/01/2005
Completion Date: 01/01/2005
Record Last Revised: 07/21/2006
Record Created: 12/08/2004
Record Released: 12/08/2004
OMB Category: Other
Record ID: 106963

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

EXPERIMENTAL TOXICOLOGY DIVISION

PULMONARY TOXICOLOGY BRANCH