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DEVELOPING AN EXPOSURE-DOSE-RESPONSE MODEL FOR THE ACUTE NEUROTOXICITY OF ORGANIC SOLVENTS: OVERVIEW AND PROGRESS ON IN VITRO MODELS AND DOSIMETRY.
Bushnell, P J., T J. Shafer, A. S. Bale, W K. Boyes, J E. Simmons, C Eklund, AND T. L. Jackson. DEVELOPING AN EXPOSURE-DOSE-RESPONSE MODEL FOR THE ACUTE NEUROTOXICITY OF ORGANIC SOLVENTS: OVERVIEW AND PROGRESS ON IN VITRO MODELS AND DOSIMETRY. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. Elsevier Online, New York, NY, 19:607-614, (2005).
This article provides an overview of the current status of an exposure-dose-response (EDR) model for the volatile organic compound toluene. This model is being developed as a vehicle for understanding the neurotoxicity of organic solvents and will be used to support risk assessments for these compounds. The model incorporates a physiologically-based toxicokinetic model for relating inhalation exposure of the solvent to internal dose and data necessary to develop a toxicodynamic model of the effects of solvents on neuronal receptors. Mechanistic links between effects of solvents on receptors in vitro and adverse effects on physiology and behavior in vivo are being developed so that in vitro test systems can be used in the future to assess issues of mixtures and cross-species extrapolation.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
NEUROBEHAVIORAL TOXICOLOGY BRANCH