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COMPUTATIONAL TOXICOLOGY: FRAMEWORK, PARTNERSHIPS, AND PROGRAM DEVELOPMENT. SEPTEMBER 29-30, 2003, RESEARCH TRIANGLE PARK, NORTH CAROLINA
Citation:
Kavlock, R J., G T. Ankley, T W. Collette, E Z. Francis, K Hammerstrom, J R. Fowle III, H A. Tilson, G Toth, P. K. Schmieder, G D. Veith, E J. Weber, D C. Wolf, AND D Young. COMPUTATIONAL TOXICOLOGY: FRAMEWORK, PARTNERSHIPS, AND PROGRAM DEVELOPMENT. SEPTEMBER 29-30, 2003, RESEARCH TRIANGLE PARK, NORTH CAROLINA. REPRODUCTIVE TOXICOLOGY 19(3):265-280, (2005).
Description:
Abstract
The EPA sponsored a workshop held September 29-30, 2003 at the EPA in RTP that was focused on a proposal entitled "A Framework for a Computational Toxicology Research Program in ORD" (www.epa.gov/computox). Computational toxicology is a new research initiative being developed within ORD. This field of research seeks to apply mathematical and computer models along with biological information to improve the understanding of toxicological issues and is considered an emerging area of research in ORD. The proposal dealt with at the workshop sets forth three strategic objectives of the emerging computational toxicology program in ORD: 1) to improve linkages in the source-to-outcome paradigm used for risk assessment by EPA, 2) to develop predictive models for hazard identification, and 3) to improve quantitative risk assessment. Involved in the workshop were EPA scientists, representatives from the FDA, EPA/OPPTS, and ORD/OSP, with introductions to the workshop by Drs. Paul Gilman and Lawrence Reiter.
The workshop had four parts: an outline of the framework for computational toxicology; related organizational strategies; scientific presentations; and related regulatory aspects. In addition, break-out group discussions were directed towards regulatory based applications and science based approaches. In the development of the Computational Toxicology Framework, it was clear that advances in technologies such as genomics, proteomics, and metabonomics would permit the construction of a research program that would incorporate these technologies into practical applications in the regulatory arena. Cross-organizational cooperation being critical to success of such an endeavor, four organizations with related strategic interests were invited to make presentations. Among the invitees were the National Toxicogenomics Center (NCT) from NIEHS, the Office of Biological and Environmental Research at the US Department of Energy, the National Center for Toxicological Research (NCTR) in the FDA, and CIIT Centers for Health Research.