EPA Science Inventory

A SYSTEMS BIOLOGY APPROACH TO DEVELOPMENTAL TOXICOLOGY

Citation:

Cummings, A M. AND R J. Kavlock. A SYSTEMS BIOLOGY APPROACH TO DEVELOPMENTAL TOXICOLOGY. REPRODUCTIVE TOXICOLOGY 19:281-290, (2005).

Description:

Abstract
Recent advances in developmental biology have yielded detailed models of gene regulatory networks (GRNs) involved in cell specification and other processes in embryonic differentiation. Such networks form the bedrock on which a systems biology approach to developmental toxicology can be built. In this review, an introduction to GRNs in general is followed by a description of specific networks involved in sea urchin and Drosophila development. A hypothesis is presented regarding the role of GRN analysis in the determination of mechanisms of chemical toxicity during embryonic development. Potential for future directions and research approaches in this area is discussed.

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Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 01/01/2005
Completion Date: 01/01/2005
Record Last Revised: 12/21/2005
Record Created: 12/08/2004
Record Released: 12/08/2004
Record ID: 104796

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

REPRODUCTIVE TOXICOLOGY DIVISION

IMMEDIATE OFFICE