EPA Science Inventory

EFFECTS OF SUBCHRONIC EXPOSURES TO CONCENTRATED AMBIENT PARTICLES: VII. DEGENERATION OF DOPAMINERGIC NEURONS IN APO E-/- MICE.

Citation:

Veronesi, B, O. Makwana, M. Pooler, AND L. C. Chen. EFFECTS OF SUBCHRONIC EXPOSURES TO CONCENTRATED AMBIENT PARTICLES: VII. DEGENERATION OF DOPAMINERGIC NEURONS IN APO E-/- MICE. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, 17:235-241, (2005).

Description:

This research describes the neuropathological consequences of subchronic exposure to particulate matter. A genetically modified animal strain (Apo E-/-) which expresses high levels of oxidative stress was exposed to ambient NYC air for 4-6 months. The brains of these animals were processed histologically and revealed neuropathic damage to the same type of neurons that degenerate in parkinsons disease. This demonstration underscores the serious interaction between the health condition of oxidative stress and exposure to chemicals that in themselves convey oxidative stress

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 02/15/2005
Completion Date: 02/15/2005
Record Last Revised: 12/21/2005
Record Created: 12/08/2004
Record Released: 12/08/2004
Record ID: 104738

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

NEUROTOXICOLOGY DIVISION

CELLULAR AND MOLECULAR TOXICOLOGY BRANCH