EPA Science Inventory

BIOMARKERS OF REPRODUCTIVE TOXICITY

Citation:

Rockett, J C. AND S J. Kim. BIOMARKERS OF REPRODUCTIVE TOXICITY. DISEASE MARKERS 1(1):93 - 108 , (2005).

Description:

Identification and verification of anatomical, endocrine, cellular and molecular biomarkers is crucial for successful clinical diagnosis and treatment of toxicity and disease, as well as basic toxicological, epidemiological and other research. Various in situ biomarkers of reproductive development and health have been identified, including those associated with pubertal development, adult reproductive health and pregnancy outcome. Herein we discuss those in situ biomarkers which have been more closely associated with toxicant action on the reproductive system. Biomarkers of toxicant exposure and susceptibility are addressed, but the majority of the review focuses on those biomarkers which may prove useful for determining current pathophysiological status or predicting future adverse outcomes. In males these are primarily associated with altered spermatogenesis and sperm parameters, and in females with altered endocrine function. We conclude that although few robust in situ biomarkers are currently available which are specific for toxicant exposure, susceptibility or effect in reproductive systems, there is expectation that post-genomic technologies offer a new paradigm for identifying and verifying such biomarkers as may exist.

Purpose/Objective:

To discuss in situ biomarkers associated with toxicant action on the reproductive system.

URLs/Downloads:

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 01/01/2005
Completion Date: 12/31/2005
Record Last Revised: 08/17/2006
Record Created: 12/08/2004
Record Released: 12/08/2004
OMB Category: Other
Record ID: 104720

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

REPRODUCTIVE TOXICOLOGY DIVISION

GAMETE AND EARLY EMBRYO BIOLOGY BRANCH