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Presentation presented to the 1st International Electronic Conference on Toxics (IECTO)Session E. Novel Methods in Toxicology Research

This is a lecture to the Colorado Produced Water Consortium to review methods that are used by EPA to evaluate chemicals and mixtures.

Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based biomonitoring guidance values, but to locate these values, interested parties need to seek them out individually fro...

With increasing public awareness of PFAS, and their presence in biological and environmental media across the globe, comes a matching increase in the number of PFAS monitoring studies. As more matrices and sample cohorts are examined, there are more opportunities for matrix inter...

Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditi...

The purpose of this letter is to correct previously reported blood serum concentrations for PFO5DoA in people in Wilmington, North Carolina (NC), in 2017-2018 [1]. Perfluoro-3,5,7,9,11-pentaoxadodecanoic acid (known as PFO5DoA; Chemical Abstracts Service Number [CASN] 39492-91-6,...

There is strong scientific evidence for multiple pathways of human exposure to lead (Pb) in residential settings, particularly for young children; however, less is known about maternal exposure during pregnancy and children’s exposure during early lifestages. A robust, mult...

Background: Complex contributions of environment to health are intimately connected to human behavior. Modeling of human behaviors helps inform important policy decisions related to critical environmental and public health challenges. There are many approaches to human behavior m...

This is a short presentation to the Subcommittee on Chemical Exposures of the President's Task Force on Environmental Health Risks and Safety Risks to Children. The presentation briefly touches on the STAR program history of ORD funding for Children's Centers, and discusses our c...

Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...

These data were recently presented at SOT 2024 as a poster, and this sub-product will present the same data and analyses in a presentation at a local society meeting of endocrine disrupting chemicals NC (EDC-NC). Sprague-Dawley rat dams were exposed via oral gavage from GD18-22 t...

EPA’s Report on the Environment (ROE) brings together the most reliable and readily available indicators to create a comprehensive view of the nation’s environmental and human health status and trends. The indicators provide an objective basis for Agency decision maki...

Background and Purpose The identification of chemicals with the potential to disrupt androgen signaling is a key component of the EPA’s Endocrine Disruption Screening Program (EDSP). EPA researchers have worked to devise in vitro assays and computational models to serve as ...

Background: While benefits of greenness to health have been reported, findings specific to child respiratory health are inconsistent. Methods: We utilized a prospective birth cohort followed from birth to age 7 years (n = 617). Residential surrounding greenness was quan...

Lead (Pb) and arsenic (As) contamination of soils is widespread in the United States and is an important source of exposure in young children. Early life exposure to metal(loid) contaminants has serious and long-lasting effects on health, making mitigation a critical public healt...

Background.  When chemical health hazards have been identified, probabilistic dose–response assessment (“hazard characterization”) quantifies uncertainty and/or variability in toxicity as a function of human exposure. Existing probabilistic approaches diffe...

Humans interact with thousands of chemicals. This study aims to identify substances of emerging concern and in need of human health risk evaluations. Sixteen pooled human serum samples were constructed from 25 individual samples each from the National Institute of Environmental H...

This is a presentation abstract for proposed session, ID 141, Advances in New Approach Methods for Thyroid Toxicity Testing, for the SOT 2024 Annual Meeting.  Abstract: There is significant regulatory need to evaluate chemicals that may disrupt the thyroid endocrine system. ...

Morphogenesis of the blood-brain barrier (BBB) is a complex process linked to neovascularization of the embryonic neural tube. This selective transport interface forms between vascular-neural compartments during organogenesis and dysregulation has be...

Background: Observational epidemiologic studies provide critical data for the evaluation of the potential effects of environmental, occupational and behavioural exposures on human health. Systematic reviews of these studies play a key role in informing policy and practice. System...

To make a dataset FAIR, it is imperative that data sets are internally consistent, nonredundant, unambiguous, and accessible. An example of making FAIR data is provided by the US EPA Integrated Risk Information System (IRIS) Program’s inclusion of the Environmental Health V...

A database of embryo-fetal developmental toxicity (EFDT) studies of 379 pharmaceutical compounds in rat and rabbit was analyzed for species differences based on toxicokinetic parameters of area under the curve (AUC) and maximum concentration (Cmax) at the developmental adverse ef...

Per and polyfluoroalkyl substances (PFAS) are a large class of fluorinated organic chemicals of interest to regulatory agencies due to their prevalence and persistence in the environment. Multiple PFAS have been identified as endocrine disrupting chemicals due to estrogen recepto...

Socially isolated individuals and communities often face psychosocial stressors in combination with exposure to high levels of air pollutants. Social isolation (SI) has been considered a risk factor for neuropsychiatric conditions and is also linked to increased metabolic disorde...

Multiple per- and polyfluoroalkyl ether acids have recently been detected in drinking water and/or human serum, but there is a paucity of data on potential toxicity despite known exposure.  Perfluoro-2-methoxyacetic acid (PFMOAA) is a short chain ether carboxylate (3 carbons...