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For many coastal areas around the Puget Sound, the interplay between weather, surface water, soils, evapotranspiration and groundwater flows is critical to modeling stream flow and predicting quantity and timing of flows under climate change. In this presentation, we introduce an...

Background: Co-exposure to air pollution and neighborhood disadvantage may influence cognitive decline. We tested these associations in the context of dementia risk. Methods: We leveraged a cohort of community dwelling adults ≥65 years (n=5,112) enrolled from 2011 to 2018 in ...

Combustion of mixed materials during open air burning of refuse or structural fires in the wildland urban interface produces emissions that worsen air quality, contaminate rivers and streams, and cause poor health outcomes including developmental effects. The zebrafish, a freshwa...

In 2018, the U.S. Environmental Protection Agency (EPA) established the EPA Environmental and Human Health Indicators Community of Practice (EHHI CoP) with members from across the agency. The purpose of the community has been to advance environmental and human health indicator[1]...

Agricultural soils are increasingly undergoing inadvertent and purposeful exposures to engineered CeO2 nanoparticles (NPs), which can impact crops and root-associated microbial communities. However, interactions between NP concentration and exposure duration on plant-mediate...

This is a poster for the 2023 National Association of City and County Health Officials (NACCHO) Conference. This poster aims to demonstrate how EPA develops and delivers resources that meet the science needs of states/territories and other entities through highlighting ORD tools ...

Bacillus anthracis, the causative agent of inhalation anthrax, is one of the most highly studied biological threat agents. Significant gaps remain related to the remediation of a wide area following such biological release. This extends to the remediation of critical assets owned...

Omics methodologies are increasingly used to inform human health risk assessment. The volume of transcriptomic data in particular has grown markedly with the commercialization of targeted sequencing approaches that enable high-throughput gene expression profiling. These technolog...

Air quality improvement has benefitted large portions of forests in the USA over the past 20 years. However, although terrestrial ecosystems are now better protected, sensitive species still experience harmful impacts, which could lead to biodiversity loss through shifts in fores...

With increasing concerns about freshwater cyanobacteria blooms, there is a need to identify which waterbodies are at risk for developing these blooms, especially those that produce cyanotoxins. To address this concern, we developed spatial statistical models using the US National...

Background: Air pollution risk assessments do not generally quantify health impacts using multipollutant risk estimates, but instead use results from single-pollutant or copollutant models. Multipollutant epidemiological models account for pollutant interactions and joint effects...

This presentation will review the latest research on inputs, budgets, effects, legacies and management related to non-point source nutrient pollution.  Using examples of nitrogen and phosphorus budgets at the national, regional and local scales, Jana Compton from EPA’s...

Pew Charitable Trusts – Peatland Mapping Workshop Series.  Amanda Nahlik is invited to present at the Peatland Mapping Workshop webinar focused on quantifying peatland extent with the goal of producing a national peatland map.  This webinar series was organized to...

This is a contributed presentation to the Monday Morning Meeting seminar series organized by the Department of Fisheries, Wildlife and Conservation Science at Oregon State University and focuses on the use of joint species distribution modeling to quantify taxon-environment relat...

Current methods for cancer risk assessment are resource-intensive and not practical for thousands of untested chemicals in the environment. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression biomarkers and associat...

Wildfires have increased in frequency and area burned, trends expected to continue with climate change. Among other effects, fires release pollutants into the atmosphere, representing a risk to human health and downwind terrestrial and aquatic ecosystems. While human health risks...

Invited Question and Answer article for Nature Cardiovascular Research on Particulate Matter.Recent air-quality alerts in major cities due to the wildfires in Canada, Hawaii and Greece have put fine particulate matter (PM) pollution and consequent health issues into the spotlight...

New approach methodologies (NAMs) are being evaluated for their utility to inform developmental neurotoxicity (DNT) hazard instead of using animals. This work compares predictive models for DNT using DNT NAMs data. The dataset comprised 200 chemicals screened in 17 DNT assays wit...

This is a public presentation on the potential effects of nutrients in smoke on downwind cyanobacteria blooms. Wildfire activity is increasing in the continental U.S. and can be linked to climate change effects, including rising temperatures and more frequent drought conditions. ...

The relationship between environmental chemical exposure and a spectrum of neurological diseases is well-established. However, unraveling the underlying mechanism between human exposure and toxic outcomes presents significant challenges. Evaluation of neurotoxicity potential usin...

The meeting aims to 1) discuss progress towards updating the Initial Recommendations to an OECD guidance, 2) discuss the regulatory implementation of the current DNT-IVB and strategy to include/exclude additional assays, and 3) discuss complementary aspects of the guidance that a...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...

The US EPA has developed a set of annual North American anthropogenic and fire emissions data for criteria air pollutants across 18 broad source catagories for 2002 through 2017.  The sixteen new annual emissions inventories were developed using consistent input data and met...

Over the past decade, a concerted effort has been made to develop in vitro and alternative assays that detect compounds with the potential to cause developmental neurotoxicity. As a result, a battery of assays has been developed that is believed to be useful for decision-making r...