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The purpose of this article is to briefly review the published literature on the developmental neurotoxic effects, including potential mechanisms of four butanols: n-butanol, sec-butanol, tert-butanol, isobutanol, and identify data gaps and research needs for evaluation of human ...

Textbook chapter on "Risk Assessment, Risk Management, and Regulation of Halogenated Organic Chemicals: Current Practice and Future Directions" for the book "Neurotoxicity of Halogenated Organic Compounds"

In April 2021, EPA released the Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials). As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conductin...

The <em>2019 Integrated Science Assessment for Particulate Matter</em> (PM ISA) provides the scientific foundation for review of the primary and secondary National Ambient Air Quality Standards (NAAQS) for particulate matter (PM). The PM ISA contains an evaluation and synthesis o...

The Ecological Risk Assessment Support Center (ERASC) announced the release of the final document, <em>Summary Report. Separating Anthropogenic Metals Contamination from Background: A Critical Review of Geochemical Evaluations and Proposal of Alternative Methodology</em>. Meaning...

EPA released the report, “ORD Staff Handbook for Developing IRIS Assessments,” or “IRIS Handbook,” which provides the operating procedures for developing assessments to the scientists in the IRIS Program. The IRIS Handbook implements recommendations and input from the National Ac...

Federal Guidance Report No. 16 (FGR 16) provides radionuclide-specific lifetime radiogenic cancer risk coefficients for the U.S. population, based on age- and gender-specific intake rates, dosimetry, and risk models. Risk coefficients are provided for external exposure to radionu...

Background: Mechanistic understanding of transient exposures that lead to adverse health outcomes will enhance our ability to recognize biological signatures of disease. Here, we measured the transcriptomic and epigenomic alterations due to exposure to the metabolic reprogramming...

The presentation prevents an overview of ORDS research on risk assessment and systems analysis of decentralized water reuse approaches to a group of graduate students in an interdisciplinary program on science, technology, engineering, and policy. The organizers are interest in p...

The Society of Environmental Toxicology and Chemistry (SETAC) convened a Pellston workshop in 2022 to examine how information on climate change could be better incorporated into the ecological risk assessment (ERA) process for chemicals as well as other environmental stressors. A...

Mass-spectrometry-based non-targeted analysis (NTA), in which mass spectrometric signals are assigned chemical identities based on a systematic collation of evidence, is a growing area of interest for toxicological risk assessment. Successful NTA results in better identification ...

Per- and polyfluoroalkyl substances (PFAS) are recognized as an urgent public health and environmental threat across the global community.&nbsp; In response, the United States Environmental Protection Agency (US EPA) has developed a PFAS Strategic Roadmap documenting commitments ...

Industrial and waste management facilities can emit air pollutants and odorous compounds from fugitive leaks, process malfunctions, and area sources that are difficult to predict, quantify, and manage. These sources can produce a range of environmental and life quality impacts an...

Poster presentation at SOT 2020 associated with abstract {All-Ages Lead Model (AALM) Batch Submission Module: A New Tool for Streamlined Human Lead Toxicokinetic Simulations} in STICS (ORD-035233)

This is a presentation to the Federal-State Toxicology Risk Analysis Committee (FSTRAC) on the development of the ORD Human Health Toxicity Values for PFPrA assessment.&nbsp; It frames the need and problem formulation, process, results, and conclusions.&nbsp;

Ecotoxicological testing to assess the effects of plant protection products on non-target terrestrial plants (NTTPs) under greenhouse conditions is conducted according to standard guidelines (e.g. OECD?208 and OECD?227). EFSA&rsquo;s Scientific Opinion of 2014 on the risk assessm...

New approach methods (NAMs) can rapidly provide mechanistic data in support of human health risk assessment, but the applicability of these data for developmental and reproductive hazards has yet to be fully interrogated. The Key Characteristics (KCs) approach provides a systemat...

&quot;Lightning Talk&quot; on high-level aspects of pharmacokinetics in risk assessment and specific issues that exist for PFAS.

Due to the diversity of non-targeted analysis (NTA) applications using high-resolution mass spectrometry, many different NTA workflows exist to support user specific needs. However, no universal, widely accepted reporting standards for NTA studies exist. The Benchmarking and Publ...

Children may be exposed to environmental contaminants through incidental ingestion of soil resulting from hand-to-mouth contact. We measured soil adherence to the skin among 86 children from four kindergartens and one elementary school in Taiwan. Rinse water samples were collecte...

Propranolol is a heavily prescribed, nonspecific beta-adrenoceptor (bAR) antagonist frequently found in wastewater effluents, prompting concern over its potential to adversely affect exposed organisms. In the present study, the transcriptional responses of 4, 5, and 6 days postfe...

Omics methodologies are increasingly used to inform human health risk assessment. The volume of transcriptomic data in particular has grown markedly with the commercialization of targeted sequencing approaches that enable high-throughput gene expression profiling. These technolog...

To cause developmental toxicity, chemical exposures must cause bioactive concentrations in key tissues during susceptible lifestages, including during early fetal development. Next generation chemical risk assessment (NGRA) aims to replace and enhance traditional toxicity testing...

Current methods for cancer risk assessment are resource-intensive and not practical for thousands of untested chemicals in the environment. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression biomarkers and associat...

Wildfires have increased in frequency and area burned, trends expected to continue with climate change. Among other effects, fires release pollutants into the atmosphere, representing a risk to human health and downwind terrestrial and aquatic ecosystems. While human health risks...