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Introduction: Studies of gastrointestinal physiology and the gut microbiome often consider the influence of intestinal region on experimental endpoints. However, this same consideration is not often applied to the gut metabolome. Understanding the contribution of gut regionality...

The Health and Environmental Sciences Institute Developmental and Reproductive Toxicology (HESI-DART) group held a hybrid in-person and virtual workshop in Washington, DC, in 2022. The workshop was entitled, "Interpretation of DART in Regulatory Contexts and Frameworks.&quot...

In March 2021, EPA released the <em>Systematic Review Protocol for the Inorganic Mercury Salts IRIS Assessment (Preliminary Assessment Materials)</em>. As part of developing a draft IRIS assessment, EPA presents a methods document, referred to as the protocol, for conducting a ch...

The U.S. Environmental Protection Agency’s (U.S. EPA) Office of Research and Development (ORD) recognized the need to develop an approach to study non-chemical stressors within a chemical stressor paradigm. Research is needed to identify which non-chemical stressors are likely to...

Microplastics are ubiquitous in the environment and present potential adverse effects on human and environmental health. EPA's Office of Research and Development is interested in developing sampling and analytical methods for microplastic detection, investigating their effects on...

The Small Communities - Big Challenges Competition was a ORD and OEJECR sponsored Challenge and Prize Competition that was open to local governments to highlight innovative and inclusive strategies for engaging with rural communities and collaboratively identifying environmental ...

Connectivity mapping is a powerful approach for relating chemicals, targets, and diseases using transcriptomic data (Lamb 2007). It assumes that transcriptomic profiles can fingerprint biological states (e.g., target activation, pathway perturbation, etc.) using the universal lan...

Antimicrobial resistance (AMR) is a global crisis threatening human, animal, and environmental health. The natural environment, specifically water resources, has been recognized as a reservoir and dissemination pathway for AMR; however, urban karst aquifer systems have been overl...

This is a talk I will give as part of the Toxics Webinar | Issue Cover Authors of 2023. I will only discuss published work that has been cleared and published in Toxics last year.

In 2018, the U.S. Environmental Protection Agency (EPA) established the EPA Environmental and Human Health Indicators Community of Practice (EHHI CoP) with members from across the agency. The purpose of the community has been to advance environmental and human health indicator[1]...

This is a poster for the 2023 National Association of City and County Health Officials (NACCHO) Conference. This poster aims to demonstrate how EPA develops and delivers resources that meet the science needs of states/territories and other entities through highlighting ORD tools ...

Background: Air pollution risk assessments do not generally quantify health impacts using multipollutant risk estimates, but instead use results from single-pollutant or copollutant models. Multipollutant epidemiological models account for pollutant interactions and joint effects...

Current methods for cancer risk assessment are resource-intensive and not practical for thousands of untested chemicals in the environment. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression biomarkers and associat...

New approach methodologies (NAMs) are being evaluated for their utility to inform developmental neurotoxicity (DNT) hazard instead of using animals. This work compares predictive models for DNT using DNT NAMs data. The dataset comprised 200 chemicals screened in 17 DNT assays wit...

The relationship between environmental chemical exposure and a spectrum of neurological diseases is well-established. However, unraveling the underlying mechanism between human exposure and toxic outcomes presents significant challenges. Evaluation of neurotoxicity potential usin...

The meeting aims to 1) discuss progress towards updating the Initial Recommendations to an OECD guidance, 2) discuss the regulatory implementation of the current DNT-IVB and strategy to include/exclude additional assays, and 3) discuss complementary aspects of the guidance that a...

Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...

Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...

Over the past decade, a concerted effort has been made to develop in vitro and alternative assays that detect compounds with the potential to cause developmental neurotoxicity. As a result, a battery of assays has been developed that is believed to be useful for decision-making r...

Background:&nbsp; Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring...

Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, cancer, and other adverse healt...

A critical step in systematic reviews of potential health hazards is the structured evaluation of the strengths and weaknesses of the included studies; risk of bias is a term often used to represent this process, specifically with respect to the evaluation of systematic errors th...

Presentation presented to the 1st International Electronic Conference on Toxics (IECTO)Session E. Novel Methods in Toxicology Research

This is a lecture to the Colorado Produced Water Consortium to review methods that are used by EPA to evaluate chemicals and mixtures.

Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based biomonitoring guidance values, but to locate these values, interested parties need to seek them out individually fro...