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Exposure Research

Records 1 to 48 of 48
2015
Mazur, Chris, S. Marchitti, AND J. Zastre. P-glycoprotein Inhibition by the Agricultural Pesticide Propiconazole and Its Hydroxylated Metabolites: Implications for Pesticide-Drug Interactions. TOXICOLOGY LETTERS. Elsevier Science Ltd, New York, NY, 232(1):37-45, (2015).
2014
Mazur, Chris, S. Marchitti, AND J. Zastre. P-glycoprotein Inhibition by the Agricultural Pesticide Propiconazole and Its Hydroxylated Metabolites: Implications for Pesticide-Drug Interactions. Presented at 19th North American ISSX Meeting, San Francisco, CA, October 19 - 23, 2014.
2013
Kenneke, J., S. Marchitti, S. Rawat, D. Chang, C. Grulke, Chris Mazur, AND Rocky Goldsmith. Chiral Pesticide Pharmacokinetics: A Range of Values. Presented at Society of Toxicology Meeting, San Antonio, TX, March 10 - 14, 2013.
Kenneke, J., S. Marchitti, S. Rawat, Chris Mazur, Q. Cheng, M. Goldsmith, D. Chang, AND C. Grulke. Impact of In Vitro System, Chemical Mistures, and Stereochemistry on the Intrinsic Clearance of 1,2,4-Triazole Fungicides in Human and Rat. Presented at The 19th International Symposium on Microsomes and Drug Oxidations and 12th European ISSX Meeting, Noordwijk aan Zee, NETHERLANDS, June 17 - 21, 2012.
2012
Mazur, Chris, S. Marchitti, M. Dimova, J. Kenneke, A. Lumen, AND J. Fisher. Human and Rat ABC Transporter Efflux of Bisphenol A and Bisphenol A Glucuronide: Interspecies Comparison and Implications for Pharmacokinetic Assessment. TOXICOLOGICAL SCIENCES. Society of Toxicology, 128(2):317-325, (2012).
2010
MAZUR, C. S., J. F. KENNEKE, J. HESS-WILSON, AND J. C. LIPSCOMB. Differences Between Human and Rat Intestinal and Hepatic Bisphenol-A Glucuronidation and the Influence of Alamethicin on In vitro Kinetic Measurements. DRUG METABOLISM AND DISPOSITION. American Society for Pharmacology and Experimental Therapeutics, Bethesda, MD, 38(12):2232-2238, (2010).
KENNEKE, J. F., D. R. EKMAN, C. S. MAZUR, B. J. Konwick, A. T. Fisk, J. K. AVANTS, AND A. W. GARRISON. Integration of Metabolomics and In vitro Metabolism Assays for Investigating the Stereoselective Transformation of Triadimefon in Rainbow Trout. Chirality. Wiley InterScience, Silver Spring, MD, 22(2):183-192, (2010).
KENNEKE, J. F., C. S. MAZUR, A. W. GARRISON, R. D. Miller, T. SACK, C. BROWN, AND J. K. AVANTS. Stereoselective Metabolism of 1,2,4-Triazole Fungicides in Hepatic Microsomes and Implications for Risk Assessment. Presented at 239th ACS National Meeting & Exposition, San Francisco, CA, March 21 - 25, 2010.
2009
KENNEKE, J. F., C. S. MAZUR, A. W. GARRISON, C. K. CUNNINGHAM, AND R. D. Miller. A Systems Approach to Assessing Risk: The Role of Metabolism Research in Describing and Predicting Exposure. Presented at 19th Annual International Society of Exposure Science Conference, Minneapolis, MN, November 01 - 05, 2009.
MAZUR, C. S., J. F. KENNEKE, M. GOLDSMITH, AND C. BROWN. Contrasting Influence of NADPH and a NADPH-Regenerating System on the Metabolism of Carbonyl-Containing Compounds in Hepatic Microsomes. DRUG METABOLISM AND DISPOSITION. American Society for Pharmacology and Experimental Therapeutics, Bethesda, MD, 37(9):1801-1805, (2009).
KENNEKE, J. F., C. S. MAZUR, W. M. HENDERSON, A. W. GARRISON, S. E. Ritger, T. J. Sack, C. C. Brown, AND J. K. Avants. Kinetics, Mechanisms and Stereoselective Metabolism of 1,2,4-Triazole Fungicides and the Implications for Human Health and Ecological Risk Assessment. Presented at 238th ACS National Meeting & Exposition, Washington, DC, August 16 - 20, 2009.
KENNEKE, J. F., C. S. MAZUR, K. A. Kellock, AND J. P. Overmyer. Mechanistic Approach to Understanding the Toxicity of the Azole Fungicide Triadimefon to a Nontarget Aquatic Insect and Implications for Exposure Assessment. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 43(14):5507-5513, (2009).
2008
MAZUR, C. S. AND J. F. KENNEKE. CROSS-SPECIES COMPARISON OF CONAZOLE FUNGICIDE METABOLITES USING RAT AND RAINBOW TROUT (<I>ONCHLORHYNCHUS MYKISS</I>) HEPATIC MICROSOMES AND PURIFIED HUMAN CYP 3A4. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 42(3):947-954, (2008).
Ritger, S., J. F. KENNEKE, C. S. MAZUR, W. M. HENDERSON, AND J. Fisher. Gender and Species-Mediated Differences in the <I>In Vitro</I> Metabolism of Triadimefon by Rodent Hepatic Microsomes. Presented at Society of Toxicology Annual Meeting, Seattle, WA, March 16 - 20, 2008.
KENNEKE, J. F., C. S. MAZUR, S. E. Ritger, AND T. SACK. Mechanistic Investigation of the Non-Cytochrome P450 Mediated Metabolism of Triadimefon and Implications for Toxicity. Presented at 4th Pan Pacific Conference on Pesticide Science, Honolulu, HI, June 01 - 05, 2008.
KENNEKE, J. F., C. S. MAZUR, S. E. RITGER, AND T. SACK. Mechanistic Investigation of the Noncytochrome P450-Mediated Metabolism of Triadimefon to Triadimenol in Hepatic Microsomes. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 21(10):1997-2004, (2008).
KENNEKE, J. F., C. S. MAZUR, W. M. HENDERSON, A. W. GARRISON, S. E. RITGER, T. SACK, C. BROWN, AND J. K. AVANTS. XENOBIOTIC METABOLISM RESEARCH AND ITS APPLICATION TO HUMAN AND ECOLOGICAL EXPOSURE AND RISK ASSESSMENT. Presented at Society of Toxicology Annual Meeting, Seattle, WA, March 16 - 20, 2008.
2007
KENNEKE, J. F., W. M. HENDERSON, A. W. GARRISON, S. RITGER, AND C. S. MAZUR. APPLICATION OF ADVANCED IN VITRO TECHNIQUES TO MEASURE, UNDERSTAND AND PREDICT THE KINETICS AND MECHANISMS OF XENOBIOTIC METABOLISM. Presented at International Science Forum on Computational Toxicology, Research Triangle Park, NC, May 21 - 23, 2007.
MAZUR, C. S. AND J. F. KENNEKE. CROSS-SPECIES COMPARISON OF CONAZOLE FUNGICIDE METABOLITES USING RAT AND RAINBOW TROUT (ONCHORHYNCHUS MYKISS) HEPATIC MICROSOMES AND PURIFIED HUMAN CYTOCHROME P450 3A4. Presented at 8th International Society for the Study of Xenobiotics, Sendai, JAPAN, October 09 - 12, 2007.
KENNEKE, J. F., C. S. MAZUR, AND A. W. GARRISON. ENANTIOSELECTIVE FORMATION OF THE TRIAZOLE FUNGICIDE TRIADIMENOL FROM TRIADIMEFON IN MAMMAL AND FISH HEPATIC MICROSOMES. Presented at 234th National American Chemical Society Meeting, Boston, MA, August 19 - 23, 2007.
JONES, W. J., C. S. MAZUR, J. F. KENNEKE, AND A. W. GARRISON. ENANTIOSELECTIVE MICROBIAL TRANSFORMATION OF THE PHENYLPYRAZOLE INSECTICIDE FIPRONIL IN ANOXIC SEDIMENTS. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 41(24):8301-8307, (2007).
MAZUR, C. S., J. F. KENNEKE, C. T. STEVENS, M. S. OKINO, AND J. C. LIPSCOMB. IN VITRO METABOLISM OF THE FUNGICIDE AND ENVIRONMENTAL CONTAMINANT TRANS-BROMUCONAZOLE AND IMPLICATIONS FOR RISK ASSESSMENT. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. Taylor & Francis, Inc., Philadelphia, PA, 70(14):1241-1250, (2007).
OVERMYER, J. P., J. F. KENNEKE, C. S. MAZUR, J. K. AVANTS, A. W. GARRISON, M. DELORENZO, AND P. KEY. USING CHIRALITY TO INFORM THE METABOLISM OF TRIADIMEFON TO TRIADIMENOL: A CROSS-SPECIES EXAMINATION. Presented at Society for Environmental Toxicology and Chemistry Annual Meeting, Milwaukee, WI, November 11 - 15, 2007.
2006
CHANG, D., T. L. WHITEHEAD, M. S. OKINO, C. S. MAZUR, J. F. KENNEKE, R. TORNERO-VELEZ, J. C. JOHNSON, AND C. C. DARY. AN IN SILICO INVESTIGATION OF THE ENANTIOSELECTIVE METABOLISM RATES OF TRIAZOLE FUGICIDES. Presented at 14th North American International Society for the Study of Xenobiotics Meeting, Rio Grande, PUERTO RICO, October 22 - 26, 2006.
CHANG, D., M. S. OKINO, FRED W. POWER, R. TORNERO-VELEZ, J. F. KENNEKE, CHRIS S. MAZUR, C. C. DARY, AND TIM W. COLLETTE. ESTIMATION OF CHEMICAL SPECIFIC PARAMETERS WITHIN PHYSIOLOGICALLY BASED PHARMACOKINETIC/PHARMACODYNAMIC MODELS. Presented at EPA Science Forum 2006, Washington, DC, May 16 - 18, 2006.
KENNEKE, J. F. AND C. S. MAZUR. IN VITRO METABOLISM RESEARCH AT NERL/ERD: AN OVERVIEW OF CONAZOLE FUNGICIDES. Presented at Metabolism Research Meeting, Research Triangle Park, NC, October 11, 2006.
CHANG, D., P. P. EGEGHY, J. B. KNAAK, R. TORNERO-VELEZ, M. S. OKINO, F. W. POWER, M. DELLARCO, C. S. MAZUR, J. F. KENNEKE, AND C. C. DARY. INFLUENCE OF MATRIX FORMULATION ON DERMAL PERCUTANEOUS ABSORPTION OF TRIAZOLE FUNGICIDES USING QSAR AND PBPK / PD MODELS. Presented at ISEA/ISEE 2006 , Paris, FRANCE, September 02 - 06, 2006.
2005
COLLETTE, T. W., D. COLON, S. H. HILAL, W. J. JONES, J. F. KENNEKE, C. S. MAZUR, C. T. STEVENS, P. WINGET, K. L. WOLFE, AND E. J. WEBER. Development of Environmental Fate and Metabolic Simulators. Presented at Bioinformatics Open Source Conference (BOSC), Detroit, MI, June 23 - 24, 2005.
KENNEKE, J. F. AND C. S. MAZUR. ENANTIOSELECTIVE IN VITRO METABOLISM OF THE TRIAZOLE FUNGICIDES BROMUCONAZOLE AND TRIADIMEFON USING RAT HEPATIC MICROSOMES. Presented at International Society for the Study of Xenobiotics Conference, Maui, HI, October 23 - 27, 2005.
KENNEKE, J. F. AND C. S. MAZUR. ENANTIOSELECTIVE IN VITRO METABOLISM OF THE TRIAZOLE FUNGICIDES BROMUCONAZOLE AND TRIADIMEFON USING RAT HEPATIC MICROSOMES. Presented at International Society for the Study of Xenobiotics Conference, Maui, HI, October 23 - 27, 2005.
MAZUR, C. S. AND J. F. KENNEKE. IN VITRO METABOLISM OF THE CHIRAL TRIAZOLE FUNGICIDE BROMUCONAZOLE 47 USING SUBSTRATE DEPLETION AND PRODUCT FORMATION KINETICS IN RAT HEPATIC MICROSOMES. Presented at 13th North American International Society for the Study of Xenobiotics Meeting, Maui, HI, October 23 - 27, 2005.
MAZUR, C. S. AND J. F. KENNEKE. IN VITRO METABOLISM OF THE CHIRAL TRIAZOLE FUNGICIDE BROMUCONAZOLE 47 USING SUBSTRATE DEPLETION AND PRODUCT FORMATION KINETICS IN RAT HEPATIC MICROSOMES. Presented at International Society for the Study of Xenobiotics Conference, Maui, HI, October 23 - 27, 2005.
KENNEKE, J. F., C. S. MAZUR, AND A. W. GARRISON. IN VITRO PHASE I METABOLISM OF THE TRIAZOLE FUNGICIDE BROMUCONAZOLE AND ITS FOUR ENANTIOMERS. Presented at 230th American Chemical Society National Meeting, Washington, DC, August 28 - September 01, 2005.
KOLANCZYK, R. C., M. A. TAPPER, B. NELSON, V. WEHINGER, J. S. DENNY, D. W. KUEHL, B. R. SHEEDY, C. S. MAZUR, J. F. KENNEKE, W. J. JONES, AND P. K. SCHMIEDER. INCREASED ENDOCRINE ACTIVITY OF XENOBIOTIC CHEMICALS AS MEDIATED BY METABOLIC ACTIVATION. Presented at Society of Environmental Toxicology and Chemistry Annual Meeting, Baltimore, MD, November 13 - 17, 2005.
Hoehamer, C. F., C S. Mazur, AND N L. Wolfe. PURIFICATION AND PARTIAL CHARACTERIZATION OF AN ACID PHOSPHATASE FROM SPIRODELA OLIGORRHIZA AND ITS AFFINITY FOR SELECTED ORGANOPHOSPHATE PESTICIDES. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 53(1):90-97, (2005).
KENNEKE, J. F., C. S. MAZUR, AND A. W. GARRISON. THE IN VITRO PHASE I METABOLISM OF THE TRIAZOLE FUNGICIDE BROMUCONAZOLE AND ITS FOUR ENANTIOMERS. Presented at 230th American Chemical Society National Meeting, Washington, DC, August 28 - September 01, 2005.
2004
Garrison, A W., D R. Ekman, J F. Kenneke, AND C S. Mazur. ENANTIOMER-SPECIFIC EFFECTS OF CHIRAL POLLUTANTS. Presented at 25th Annual Meeting of the Society of Environmental Toxicology and Chemistry, Portland, OR, November 14-18, 2004.
2003
Jones, W J., W. L. O'Niell, C S. Mazur, J F. Kenneke, AND A W. Garrison. ENANTIOSELECTIVE TRANSFORMATION OF CHIRAL PCBS AND FIPRONIL IN ANOXIC SEDIMENTS. Presented at 23rd International Symposium on Halogenated Organic Pollutants and Persistent Organic Pollutants, Boston, MA, August 24-29, 2003.
Jones, W J., W. L. O'Niell, C S. Mazur, J F. Kenneke, AND A W. Garrison. ENANTIOSELECTIVE TRANSFORMATION OF CHIRAL PCBS AND THE INSECTICIDE FIPRONIL IN NATURAL ANOXIC SEDIMENTS. Presented at 23rd International Symposium on Halogenated Organic Pollutants and Persistent Organic Pollutants, Boston, MA, August 24-29, 2003.
Jones, W J., C S. Mazur, AND C L. TebesStevens. H2 CONSUMPTION DURING THE MICROBIAL REDUCTIVE DEHALOGENATION OF CHLORINATED PHENOLS AND TETRACHLOROETHENE. BIODEGRADATION 14(4):285-295, (2003).
Weber, E J., T W. Collette, W J. Jones, J F. Kenneke, C S. Mazur, L A. Suarez, C T. Stevens, J W. Washington, K Wolfe, N L. Wolfe, G W. Bailey, AND R S. Parmar. MODELING CHEMICAL FATE AND METABOLISM FOR COMPUTATIONAL TOXICOLOGY. Presented at Science Forum 2003, Washington, DC, May 5-7, 2003.
2002
Hoehamer, C. F., C S. Mazur, AND N L. Wolfe. ISOLATION AND PARTIAL CHARACTERIZATION OF AN ACID PHOSPHATASE ACTIVITY FROM SPIRODELA OLIGORHIZA. Presented at Sixth International Symposium on Environmental Biotechnology and Fourth International Symposium on Cleaner Bioprocesses and Sustainable Development, Vera Cruz, Mexico, June 9-12, 2002.
2001
Mazur, C S. AND W J. Jones. HYDROGEN CONCENTRATIONS IN SULFATE-REDUCING ESTUARINE SEDIMENTS DURING PCE DEHALOGENATION. ENVIRONMENTAL SCIENCE & TECHNOLOGY 35(24):4783-4788, (2001).
2000
Mazur, C S. AND W J. Jones. COMPARISON OF HYDROGEN CONCENTRATIONS IN PCE-DEHALOGENATING AND SULFATE-REDUCING ESTUARINE SEDIMENTS. Presented at 220th American Chemical Society National Meeting, Washington, DC, August 20-24, 2000.
Wolfe, N L., O. Prakash, C. F. Hoehamer, AND C S. Mazur. ENZYMATIC PROCESSES USED BY PLANTS TO DEGRADE ORGANIC COMPOUNDS. Presented at US Environmental Protection Agency Phytoremediation Conference, Boston, MA, May 1-2, 2000.
Gao, J, A W. Garrison, C S. Mazur, N L. Wolfe, AND C. F. Hoehamer. UPTAKE AND PHYTOTRANSFORMATION OF O,P'-DDT AND P,P'-DDT BY AXENICALLY CULTIVATED AQUATIC PLANTS. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 48(12):6121-6127, (2000).
Gao, J, A W. Garrison, C S. Mazur, N L. Wolfe, AND C. F. Hoehamer. UPTAKE AND PHYTOTRANSFORMATION OF ORGANOPHOSPHORUS PESTICIDES BY AXENICALLY CULTIVATED AQUATIC PLANTS. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 48(12):6114-6120, (2000).
1999
Mack, E. E., J W. Beck, C S. Mazur, AND W J. Jones. ENVIRONMENTAL CHARACTERISTICS AFFECTING REDUCTIVE TRANSFORMATION OF ORGANIC POLLUTANTS IN ANOXIC SEDIMENTS. Presented at 20th Annual Society of Environmental Toxicology and Chemistry Meeting, Philadelphia, PA, November 14-18, 1999.


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