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2020
Krewski, D., M. Andersen, M. Tyshenko, K. Krishnan, T. Hartung, K. Boekelheide, J. Wambaugh, D. Jones, M. Whelan, R. Thomas, C. Yauk, T. Barton-Maclaren, AND I. Cote. (Archives of Toxicology) Toxicity Testing in the 21st Century: Progress in the Past Decade and Future Perspectives. Archives of Toxicology. Springer, New York, NY, 94(1):1-58, (2020). https://doi.org/10.1007/s00204-019-02613-4
Nyffeler, J., C. Willis, R. Lougee, A. Richard, K. Friedman, AND J. Harrill. Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, 389:114876, (2020). https://doi.org/10.1016/j.taap.2019.114876
Mansouri, K., N. Kleinstreuer, R. Judson, A. Williams, I. Shah, AND A. Richard. CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 128(2):27002, (2020). https://doi.org/10.1289/EHP5580
Schymanski, E., N. Baker, A. Williams, R. Singh, J. Trezzi, P. Wilmes, P. Kolber, R. Kruger, N. Paczia, C. Linster, AND R. Balling. Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges. Environmental Science: Processes & Impacts. RSC Publishing, Cambridge, Uk, 21:1426-1445, (2019). https://doi.org/10.1039/c9em00068b
Sayre, R., J. Wambaugh, AND C. Grulke. Database of pharmacokinetic time-series data and parameters for 144 environmental chemicals. Scientific Data. Springer Nature, New York, NY, 7:122, (2020). https://doi.org/10.1038/s41597-020-0455-1
Linakis, M., R. Sayre, R. Pearce, Mark A. Sfeir, N. Sipes, H. Pangburn, J. Gearhart, AND J. Wambaugh. Development and Evaluation of a High Throughput Inhalation Model for Organic Chemicals. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 30(5):866-877, (2020). https://doi.org/10.1038/s41370-020-0238-y
Deisenroth, C., V. Soldatow, J. Ford, W. Stewart, C. Brinkman, E. LeCluyse, D. Macmillan, AND R. Thomas. Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening (ToxSci). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 174(1):63-78, (2020). https://doi.org/10.1093/toxsci/kfz238
Borrel, A., R. Huang, S. Sakamuru, M. Xia, A. Simeonov, K. Mansouri, K. Houck, R. Judson, AND N. Kleinstreuer. High-Throughput Screening to Predict Chemical-Assay Interference. Scientific Reports. Nature Publishing Group, London, Uk, 10:3986, (2020). https://doi.org/10.1038/s41598-020-60747-3
Wegner, S., C. Pinto, C. Ring, AND J. Wambaugh. High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 137:105470, (2020). https://doi.org/10.1016/j.envint.2020.105470
Allen, T., M. Nelms, S. Edwards, J. Goodman, S. Gutsell, AND P. Russell. In Silico Guidance for In Vitro Androgen and Glucocorticoid Receptor ToxCast Assays. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 54(12):7461-7470, (2020). https://doi.org/10.1021/acs.est.0c01105
Saili, K., T. Antonijevic, T. Zurlinden, I. Shah, C. Deisenroth, AND T. Knudsen. Molecular characterization of a toxicological tipping point during human stem cell differentiation. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 91(January 2020):1-13, (2020). https://doi.org/10.1016/j.reprotox.2019.10.001
Zurlinden, T., K. Saili, N. Rush, P. Kothiya, R. Judson, K. Houck, E. Hunter, N. Baker, J. Palmer, R. Thomas, AND T. Knudsen. Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 174(2):189-209, (2020). https://doi.org/10.1093/toxsci/kfaa014
Hallinger, D., H. Lindsay, K. Friedman, D. Suarez, AND S. Simmons. Respirometric Screening and Characterization of Mitochondrial Toxicants Within the ToxCast Phase I and II Chemical Libraries. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(1):175-192, (2020). https://doi.org/10.1093/toxsci/kfaa059
Judson, R., K. Houck, K. Friedman, J. Brown, P. Browne, P. Johnston, D. Close, K. Mansouri, AND N. Kleinstreuer. Selecting a Minimal set of Androgen Receptor Assays for Screening Chemicals. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 117(November 2020):104764, (2020). https://doi.org/10.1016/j.yrtph.2020.104764
Pradeep, P., G. Patlewicz, R. Pearce, J. Wambaugh, B. Wetmore, AND R. Judson. Using Chemical Structure Information to Develop Predictive Models for In Vitro Toxicokinetic Parameters to Inform High-throughput Risk-assessment. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 16:100136, (2020). https://doi.org/10.1016/j.comtox.2020.100136
Friedman, K., M. Gagne, L. Loo, P. Karamertzanis, T. Netzeva, T. Sobanski, J. Franzosa, A. Richard, R. Lougee, A. Gissi, J. Lee, M. Angrish, J. Dorne, S. Foster, K. Raffaele, T. Bahadori, M. Gwinn, J. Lambert, M. Whelan, M. Rasenberg, T. Barton-Maclaren, AND R. Thomas. Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 173(1):202-225, (2020). https://doi.org/10.1093/toxsci/kfz201
Rivetti, C., T. Allen, J. Brown, E. Butler, P. Carmichael, J. Colbourne, M. Dent, F. Falciani, L. Gunnarsson, S. Gutsell, J. Harrill, G. Hodges, P. Jennings, R. Judson, A. Kienzler, L. Margiotta-Casaluci, I. Muller, S. Owen, C. Rendal, P. Russell, S. Scott, F. Sewell, I. Shah, I. Sorrel, M. Viant, C. Westmoreland, A. White, AND B. Campos. Vision of a near future: bridging the Human Health – Environment divide. Toward an integrated strategy to understand mechanisms across species for chemical safety assessment. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 62:104692, (2020). https://doi.org/10.1016/j.tiv.2019.104692
2019
Patlewicz, G., A. Richard, A. Williams, C. Grulke, R. Sams, J. Lambert, Pamela Noyes, M. DeVito, R. Hines, M. Strynar, A. GuiseppiElie, AND R. Thomas. A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 127(1):1-12, (2019). https://doi.org/10.1289/EHP4555
Wetmore, B., R. Clewell, B. Cholewa, B. Parks, S. Pendse, M. Black, K. Mansouri, S. Haider, E. Berg, R. Judson, K. Houck, M. Martin, H. Clewell III, M. Andersen, R. Thomas, AND P. McMullen. Assessing Bioactivity-Exposure Profiles of Fruits and Vegetables in the BioMAP Profiling System. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 54:41-57, (2019). https://doi.org/10.1016/j.tiv.2018.09.006
Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, AND R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2):235-251, (2019). https://doi.org/10.1093/toxsci/kfz205
Philips, J., D. Svoboda, A. Tandon, S. Patel, A. Sedykh, D. Mav, B. Kuo, C. Yauk, L. Yang, R. Thomas, Jeff Gift, Allen Davis, L. Olysyzk, F. Parham, T. Saddler, R. Shah, S. Auerbach, B. Merrick, AND R. Paules. BMDExpress 2: Enhanced transcriptomic dose-response analysis workflow. BIOINFORMATICS. Oxford University Press, Cary, NC, 35(10):1780-1782, (2019). https://doi.org/10.1093/bioinformatics/bty878
Ellison, C., K. Blackburn, P. Carmichael, H. Clewell, M. Cronin, B. Desprez, S. Escher, S. Fergusson, S. Gregoire, N. Hewitt, H. Hollnagel, M. Klaric, A. Patel, S. Salhi, A. Schepky, B. Schmitt, J. Wambaugh, AND A. Worth. Challenges in working towards an internal Threshold of Toxicological Concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop. REGULATORY TOXICOLOGY AND PHARMACOLOGY. Elsevier Science Ltd, New York, NY, 103(1):63-72, (2019). https://doi.org/10.1016/j.yrtph.2019.01.016
Baker, N., N. Sipes, J. Franzosa, D. Belair, B. Abbott, R. Judson, AND T. Knudsen. Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature. Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, , 1-21, (2019). https://doi.org/10.1002/bdr2.1581
Nelms, M., R. Lougee, D. Roberts, A. Richard, AND G. Patlewicz. Comparing and contrasting the coverage of publicly available structural alerts for protein binding. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 12:100100, (2019). https://doi.org/10.1016/j.comtox.2019.100100
Ring, C., J. Arnot, D. Bennett, P. Egeghy, P. Fantke, L. Huang, K. Isaacs, O. Jolliet, K. Phillips, P. Price, H. Shin, J. Westgate, R. Setzer, AND J. Wambaugh. Consensus Modeling of Median Chemical Intake for the U.S. Population Based on Predictions of Exposure Pathways. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 53(2):719-732, (2019). https://doi.org/10.1021/acs.est.8b04056