Office of Research and Development Publications

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Deisenroth, C., V. Soldatow, J. Ford, W. Stewart, C. Brinkman, E. LeCluyse, D. Macmillan, AND R. Thomas. Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening (ToxSci). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 174(1):63-78, (2020). https://doi.org/10.1093/toxsci/kfz238

Wegner, S., C. Pinto, C. Ring, AND J. Wambaugh. High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity. ENVIRONMENT INTERNATIONAL. Elsevier B.V., Amsterdam, Netherlands, 137:105470, (2020). https://doi.org/10.1016/j.envint.2020.105470

Pradeep, P., G. Patlewicz, R. Pearce, J. Wambaugh, B. Wetmore, AND R. Judson. Using Chemical Structure Information to Develop Predictive Models for In Vitro Toxicokinetic Parameters to Inform High-throughput Risk-assessment. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 16:100136, (2020). https://doi.org/10.1016/j.comtox.2020.100136

Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, AND R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2):235-251, (2019). https://doi.org/10.1093/toxsci/kfz205

Helman, G., I. Shah, A. Williams, J. Edwards, J. Dunne, AND G. Patlewicz. Generalised Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard. ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 36(1):1-5, (2019). https://doi.org/10.14573/altex.1811292

Wambaugh, J., M. Hughes, C. Ring, D. MacMillan, J. Ford, T. Fennell, S. Black, R. Snyder, N. Sipes, B. Wetmore, J. Westerhout, Woodrow Setzer, R. Pearce, J. Simmons, AND R. Thomas. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1):152-169, (2018). https://doi.org/10.1093/toxsci/kfy020

Bell, S., X. Chang, J. Wambaugh, D. Allen, M. Bartels, K. Brouwer, W. Casey, N. Choksi, S. Ferguson, G. Fraczkiewicz, A. Jarabek, A. Ke, A. Lumen, S. Lynn, A. Paini, Paul S Price, C. Ring, T. Simon, N. Sipes, C. Sprankle, J. Strickland, J. Troutman, B. Wetmore, AND N. Kleinstreuer. In vitro to in vivo extrapolation for high throughput prioritization and decision making. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 47:213-227, (2018). https://doi.org/10.1016/j.tiv.2017.11.016

Phillips, K., A. Yau, K. Favela, K. Isaacs, A. McEachran, Chris Grulke, A. Richard, A. Williams, J. Sobus, R. Thomas, AND J. Wambaugh. Suspect Screening Analysis of Chemicals in Consumer Products. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 52(5):3125-3135, (2018). https://doi.org/10.1021/acs.est.7b04781

Watt, Eric AND R. Judson. Uncertainty Quantification in ToxCast High Throughput Screening. PLOS Computational Biology. Public Library of Science, San Francisco, CA, 13(7):1-23, (2018). https://doi.org/10.1371/journal.pone.0196963

Pradeep, P., K. Mansouri, G. Patlewicz, AND R. Judson. A systematic evaluation of analogs and automated read-across prediction of estrogenicity: A case study using hindered phenols. Computational Toxicology. Elsevier B.V., Amsterdam, Netherlands, 4:22-30, (2017).

Saili, K., T. Zurlinden, A. Schwab, A. Silvin, N. Baker, S. Hunter, F. Ginhoux, AND T. Knudsen. Blood-Brain Barrier Development: Systems Modeling and Predictive Toxicology. Birth Defects Research, Part C: Embryo Today: Reviews. John Wiley & Sons, Ltd., Indianapolis, IN, 109(20):1680-1710, (2017). https://doi.org/10.1002/bdr2.1180

Pearce, R., Woodrow Setzer, C. Strope, N. Sipes, AND J. Wambaugh. HTTK: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software. American Statistical Association, Alexandria, VA, 79(4):1-26, (2017).

Ring, C., R. Pearce, Woodrow Setzer, B. Wetmore, AND J. Wambaugh. Identifying populations sensitive to environmental chemicals by simulating toxicokinetic variability. ENVIRONMENT INTERNATIONAL. Elsevier Science Ltd, New York, NY, 106:105-118, (2017).

Ball, N., M. Cronin, J. Shen, M. Adenuga, K. Blackburn, E. Booth, M. Bouhifd, B. Donley, L. Egnash, J. Freeman, C. Hastings, D. Juberg, A. Kleensang, N. Kleinstreuer, D. Kroese, T. Luechtefeld, A. Maertens, S. Marty, J. Naciff, J. Palmer, D. Pamies, M. Penman, A. Richarz, D. Russo, D. Steup, S. Stuard, G. Tier, B. van Ravenzwaay, S. Wu, H. Zhu, AND T. Hartung. CAAT Altex workshop paper entitled "Towards Good Read-Across Practice (GRAP) Guidance". ALTEX. Society ALTEX Edition, Kuesnacht, Switzerland, 33(2):149-166, (2016).

Slob, W. AND Woodrow Setzer. Shape and Steepness of Toxicological Dose-Response Relationships of Continuous Endpoints. CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, 44(3):270-297, (2014).

WAMBAUGH, J. F., R. W. SETZER, D. REIF, S. GANGWAL, J. MITCHELLBLACKWOOD, J. A. ARNOT, O. JOLIET, A. FRAME, J. R. RABINOWITZ, T. B. KNUDSEN, R. S. JUDSON, P. P. EGEGHY, D. A. VALLERO, AND E. A. COHEN HUBAL. High-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project . Jerald Schnoor (ed.), ENVIRONMENTAL SCIENCE AND TECHNOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 47(15):8479-8488, (2013).

JUDSON, R., R. J. KAVLOCK, R. W. SETZER, E. A. COHEN-HUBAL, M. T. MARTIN, T. B. KNUDSEN, K. A. HOUCK, R. S. THOMAS, B. A. WETMORE, AND D. J. DIX. Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 24(4):451-462, (2011).

MORTENSEN, H. M. AND S. EULING. Integrating mechanistic and polymorphism data to characterize human genetic susceptibility for environmental chemical risk assessment in the 21st century. TOXICOLOGY AND APPLIED PHARMACOLOGY. Elsevier BV, AMSTERDAM, Netherlands, (Online):1-10, (2011).

BENFORD, D., M. DINOVI, AND R. W. SETZER. Application of the Margin of Exposure (MoE) Approach to Substances in Food that are Genotoxic and Carcinogenic Example: Benzo[a]pyrene and polycyclic aromatic hydrocarbons. FOOD AND CHEMICAL TOXICOLOGY. Elsevier Science Ltd, New York, NY, 48(1):S2-S24, (2010).

Xu, Y., E. A. COHEN-HUBAL, AND J. C. Little. Predicting Residential Exposure to Phthalate Plasticizer Emitted from Vinyl Flooring: Sensitivity, Uncertainty, and Implications for Biomonitoring. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 118(2):253-8, (2010).

WAMBAUGH, J. F. AND I. A. SHAH. Simulating Microdosimetry in a Virtual Hepatic Lobule. PLOS Computational Biology. Public Library of Science, San Francisco, CA, 6(4):1-16, (2010).

SOETAERT, K., T. PETZOLDT, AND R. W. SETZER. Solving Differential Equations in R: Package deSolve. Journal of Statistical Software. American Statistical Association, Alexandria, VA, 33(9):1-25, (2010).

Lou, I., J. F. WAMBAUGH, C. LAU, R. HANSON, A. B. LINDSTROM, M. STRYNAR, R. ZEHR, R. W. SETZER, AND H. A. BARTON. Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice (J). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 107(2):331-41, (2009).

RODRIGUEZ, C. E., R. W. SETZER, AND H. A. BARTON. Pharmacokinetic Modeling of Perfluorooctanoic Acid During Gestation and Lactation in the Mouse. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 3-4:373-86, (2009).

WAMBAUGH, J. F., H. A. BARTON, AND R. W. SETZER. Comparing models for perfluorooctanoic acid pharmacokinetics using Bayesian analysis. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS. Springer, New York, NY, 35(6):683-712, (2008).