Office of Research and Development Publications

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Saili, K., T. Antonijevic, T. Zurlinden, I. Shah, C. Deisenroth, AND T. Knudsen. Molecular characterization of a toxicological tipping point during human stem cell differentiation. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 91(January 2020):1-13, (2020). https://doi.org/10.1016/j.reprotox.2019.10.001

Zurlinden, T., K. Saili, N. Rush, P. Kothiya, R. Judson, K. Houck, E. Hunter, N. Baker, J. Palmer, R. Thomas, AND T. Knudsen. Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 174(2):189-209, (2020). https://doi.org/10.1093/toxsci/kfaa014

Wei, Z., S. Sakamuru, L. Zhang, J. Zhao, R. Huang, N. Kleinstreuer, Y. Chen, Y. Shu, T. Knudsen, AND M. Xia. Identification and profiling of environmental chemicals that inhibit the TGFβ/SMAD signaling pathway. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 32(12):2433-2444, (2019). https://doi.org/10.1021/acs.chemrestox.9b00228

Baker, N., N. Sipes, J. Franzosa, D. Belair, B. Abbott, R. Judson, AND T. Knudsen. Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature. Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, , 1-21, (2019). https://doi.org/10.1002/bdr2.1581

Saili, K., J. Franzosa, N. Baker, R. Ellis-Hutchings, R. Settivari, E. Carney, R. Spencer, T. Zurlinden, N. Kleinstreuer, S. Li, M. Xia, AND T. Knudsen. Systems Modeling of Developmental Vascular Toxicity. Current Opinion in Toxicology. Elsevier BV, AMSTERDAM, Netherlands, 15(1):55-63, (2019). https://doi.org/10.1016/j.cotox.2019.04.004

Stapleton, P., C. Wingard, T. Nurkiewicz, A. Holloway, J. Zelikoff, T. Knudsen, AND L. Rogers. Cardiopulmonary consequences of gestational toxicant exposure: symposium overview at the 56th Annual SOT Meeting, Baltimore, MD. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 79(1):16-20, (2018). https://doi.org/10.1016/j.reprotox.2018.04.016

Scialli, A., G. Daston, C. Chen, P. Coder, S. Euling, J. Foreman, A. Hoberman, J. Hui, T. Knudsen, S. Makris, L. Morford, A. Piersma, D. Stanislaus, AND K. Thompson. Rethinking Developmental Toxicity Testing: Evolution or Revolution? Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, 110(10):840-850, (2018). https://doi.org/10.1002/bdr2.1212

Baker, N., A. Boobis, L. Burgoon, E. Carney, R. Currie, E. Fritsche, T. Knudsen, M. Laffont, A. Piersma, A. Poole, S. Schneider, AND G. Daston. Building a Developmental Toxicity Ontology. BIRTH DEFECTS RESEARCH PART B: DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 110(6):502-518, (2018). https://doi.org/10.1002/bdr2.1189

Nguyen, E., W. Daly, N. Le, M. Farnoodian, D. Belair, M. Schwartz, C. Lebakken, G. Ananiev, M. Saghiri, T. Knudsen, N. Sheibani, AND W. Murphy. Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion. Nature Communications. Nature Publishing Group, London, Uk, 1(0096):1-34, (2018). https://doi.org/10.1038/s41551-017-0096

Knudsen, T., B. Klieforth, AND W. Slikker. Programming Microphysiological Systems for Children’s Health Protection. Experimental Biology and Medicine. SAGE Publications, THOUSAND OAKS, CA, 242(16):1586-1592, (2017). https://doi.org/10.1177/1535370217717697

Saili, K., T. Zurlinden, A. Schwab, A. Silvin, N. Baker, S. Hunter, F. Ginhoux, AND T. Knudsen. Blood-Brain Barrier Development: Systems Modeling and Predictive Toxicology. Birth Defects Research, Part C: Embryo Today: Reviews. John Wiley & Sons, Ltd., Indianapolis, IN, 109(20):1680-1710, (2017). https://doi.org/10.1002/bdr2.1180

Baker, N., T. Knudsen, AND A. Williams. Abstract Sifter: a comprehensive front-end system to PubMed. F1000 Research. Faculty of 1000, London, Uk, 6:1-10, (2017). https://doi.org/10.12688/f1000research.12865.1

Juberg, D., T. Knudsen, M. Sander, N. Beck, E. Faustman, D. Mendrick, J. Fowle, T. Hartung, R. Tice, E. Lamazurier, R. Becker, S. Fitzpatrick, G. Daston, A. Harill, R. Hines, D. Keller, J. Lipscomb, D. Watson, T. Bahadori, AND K. Crofton. FutureTox III: Bridges for Translation. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 155(1):22-31, (2017).

Hutson, S., M. Leung, N. Baker, R. Spencer, AND T. Knudsen. Computational Model of Secondary Palate Fusion and Disruption. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 30(4):965-979, (2017).

McCollum, C., J. Conde Vancells, C. Hans, M. Vazquez-Chantada, N. Kleinstreuer, T. Tal, T. Knudsen, S. Shah, F. Merchant, R. Finnell, J. Gustafsson, R. Cabrera, AND M. Bondesson. Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 70:60-69, (2017).

Ellis-Hutchings, R., R. Settivari, A. McCoy, N. Kleinstreuer, J. Franzosa, T. Knudsen, AND E. Carney. EMBRYONIC VASCULAR DISRUPTION ADVERSE OUTCOMES: LINKING HIGH THROUGHPUT SIGNALING SIGNATURES WITH FUNCTIONAL CONSEQUENCES. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 70:82-96, (2017). https://doi.org/10.1016/j.reprotox.2017.05.005

Theunissen, P., S. Beken, B. Beyer, W. Breslin, G. Cappon, C. Chen, G. Chmielewski, L. De Schaepdrijver, B. Enright, J. Foreman, W. Harrouk, K. Hew, A. Hoberman, J. Hui, TB Knudsen, S. Laffan, S Makris, AND M Martin. Comparing rat and rabbit embryo-fetal developmental toxicity studies for 379 pharmaceuticals: On systemic dose and developmental effects (Critical Reviews in Toxicology) . CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, , 1-13, (2016).

Theunissen, P., S. Beken, B. Beyer, W. Breslin, G. Cappon, C. Chen, G. Chmielewski, L. De Schaepdrijver, B. Enright, J. Foreman, W. Harrouk, K. Hew, A. Hoberman, J. Hui, TB Knudsen, S. Laffan, S Makris, M Martin, M. McNerney, C. Siezen, D. Stanislaus, J. Stewart, K. Thompson, B. Tornesi, G. Weinbauer, S. Wood, J. Van der Laan, AND A. Piersma. Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects (Critical Reviews in Toxicology) . CRITICAL REVIEWS IN TOXICOLOGY. CRC Press LLC, Boca Raton, FL, , 1-11, (2016).

Richard, A., R. Judson, K. Houck, C. Grulke, P. Volarath, I. Thillainadarajah, C. Yang, J. Rathman, M. Martin, J. Wambaugh, T. Knudsen, K. Mansouri, J. Kancherla, G. Tier, A. Williams, S. Little, K. Crofton, AND R. Thomas. The ToxCast Chemical Landscape - Paving the Road to 21st Century Toxicology. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 29(8):1225-1251, (2016).

Knudsen, T., D. Keller, M. Sander, E. Carney, N. Doerrer, D. Eaton, S. Fitzpatrick, K. Hastings, D. Mendric, R. Tice, P. Watkins, AND M. Whelan. FORUM - FutureTox II: In vitro Data and In Silico Models for Predictive Toxicology. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 143(2):256–267, (2015).

Judson, R., K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh, Woodrow Setzer, P. Kothiya, J. Phuong, D. Filer, D. Smith, D. Reif, D. Rotroff, N. Kleinstreuer, N. Sipes, M. Xia, R. Huang, K. Crofton, AND R. Thomas. Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 152(2):323-339, (2016).

Belair, D., M. Schwartz, T. Knudsen, AND W. Murphy. Human iPSC-Derived Endothelial Cell Sprouting Assay in Synthetic Hydrogel Arrays. Acta Biomaterialia. Elsevier B.V., Amsterdam, Netherlands, 39:12-24, (2016).

Leung, M., J. Phuong, N. Baker, N. Sipes, G. Klinefelter, M. Martin, K. McLaurin, Woodrow Setzer, S. Darney, R. Judson, AND T. Knudsen. Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 124(7):1050-1061, (2016).

Shah, I., Woodrow Setzer, J. Jack, K. Houck, R. Judson, T. Knudsen, J. Liu, M. Martin, D. Reif, Ann M. Richard, Russell S. Thomas, K. Crofton, David J. Dix, AND Robert J. Kavlock. Using ToxCast data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 124(7):910-919, (2016).

Leung, Maxwell C.K., S. Hutson, A. Seifert, R. Spencer, AND T. Knudsen. Computational Modeling and Simulation of Genital Tubercle Development. REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, , 1-11, (2016).