Office of Research and Development Publications

Linakis, M., R. Sayre, R. Pearce, Mark A. Sfeir, N. Sipes, H. Pangburn, J. Gearhart, AND J. Wambaugh. Development and Evaluation of a High Throughput Inhalation Model for Organic Chemicals. Journal of Exposure Science and Environmental Epidemiology . Nature Publishing Group, London, Uk, 30(5):866-877, (2020). https://doi.org/10.1038/s41370-020-0238-y

Baker, N., N. Sipes, J. Franzosa, D. Belair, B. Abbott, R. Judson, AND T. Knudsen. Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature. Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, , 1-21, (2019). https://doi.org/10.1002/bdr2.1581

Honda, G., R. Pearce, L. Pham, R. Setzer, B. Wetmore, N. Sipes, J. Gilbert, B. Franz, R. Thomas, AND J. Wambaugh. Using the Concordance of In Vitro and In Vivo Data to Evaluate Extrapolation Assumptions. PLOS ONE . Public Library of Science, San Francisco, CA, 14(5):1-33, (2019). https://doi.org/10.1371/journal.pone.0217564

Bell, S., X. Chang, J. Wambaugh, D. Allen, M. Bartels, K. Brouwer, W. Casey, N. Choksi, S. Ferguson, G. Fraczkiewicz, A. Jarabek, A. Ke, A. Lumen, S. Lynn, A. Paini, Paul S Price, C. Ring, T. Simon, N. Sipes, C. Sprankle, J. Strickland, J. Troutman, B. Wetmore, AND N. Kleinstreuer. In vitro to in vivo extrapolation for high throughput prioritization and decision making. TOXICOLOGY IN VITRO. Elsevier Science Ltd, New York, NY, 47:213-227, (2018). https://doi.org/10.1016/j.tiv.2017.11.016

Sipes, N., J. Wambaugh, R. Pearce, S. Auerbach, B. Wetmore, J. Hsieh, A. Shapiro, D. Sboboda, M. DeVito, AND S. Ferguson. An Intuitive Approach for Predicting Human Risk with the Tox21 10k Library. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, (51):10786-10796, (2017).

Wambaugh, J., M. Hughes, C. Ring, D. MacMillan, J. Ford, T. Fennell, S. Black, R. Snyder, N. Sipes, B. Wetmore, J. Westerhout, Woodrow Setzer, R. Pearce, J. Simmons, AND R. Thomas. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1):152-169, (2018). https://doi.org/10.1093/toxsci/kfy020

Pearce, R., Woodrow Setzer, C. Strope, N. Sipes, AND J. Wambaugh. HTTK: R Package for High-Throughput Toxicokinetics. Journal of Statistical Software. American Statistical Association, Alexandria, VA, 79(4):1-26, (2017).

Judson, R., K. Houck, M. Martin, A. Richard, T. Knudsen, I. Shah, S. Little, J. Wambaugh, Woodrow Setzer, P. Kothiya, J. Phuong, D. Filer, D. Smith, D. Reif, D. Rotroff, N. Kleinstreuer, N. Sipes, M. Xia, R. Huang, K. Crofton, AND R. Thomas. Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 152(2):323-339, (2016).

Leung, M., J. Phuong, N. Baker, N. Sipes, G. Klinefelter, M. Martin, K. McLaurin, Woodrow Setzer, S. Darney, R. Judson, AND T. Knudsen. Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 124(7):1050-1061, (2016).

Judson, Richard S., F. Magpantay, V. Chickarmane, C. Haskell, N. Tania, J. Taylor, M. Xia, R. Huang, D. Rotroff, D. Filer, K. Houck, M. Martin, N. Sipes, A. Richard, K. Mansouri, Woodrow Setzer, T. Knudsen, K. Crofton, AND R. Thomas. Integrated Model of Chemical Perturbations of a Biological PathwayUsing 18 In Vitro High Throughput Screening Assays for the Estrogen Receptor. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, :1-42, (2015).

Rotroff, D., M. Martin, D. Dix, D. Filer, K. Houck, T. Knudsen, N. Sipes, D. Reif, M. Xia, R. Huang, AND R. Judson. Predictive Endocrine Testing in the 21st Century Using In Vitro Assays of Estrogen Receptor Signaling Responses. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, 48:8706-8716, (2014).

WAMBAUGH, J. F., WOODROW SETZER, A. M. Pitruzzello, J. Liu, D. M. Reif, N. C. Kleinstreuer, N. Y. WANG, N. SIPES, M. T. MARTIN, K. DAS, J. C. DeWitt, M. STRYNAR, R. JUDSON, K. A. HOUCK, AND C. LAU. Dosimetric Anchoring of In Vivo and In Vitro Studies for Perfluorooctanoate and Perfluorooctanesulfonate. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 136(2):308-327, (2013).

Judson, R., K. Houck, M. Martin, T. Knudsen, R. Thomas, N. Sipes, I. Shah, J. Wambaugh, AND K. Crofton. In Vitro and Modeling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Program. BASIC AND CLINICAL PHARMACOLOGY AND TOXICOLOGY. Blackwell Publishing, Malden, MA, 115(1):69-76, (2014).

Sipes, N., M. Martin, P. Kothiya, D. Reif, R. Judson, A. Richard, K. Houck, D. Dix, R. Kavlock, AND T. Knudsen. Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 26:878−895, (2013).

SIPES, N. S., M. T. MARTIN, D. M. REIF, N. C. KLEINSTREUER, R. S. JUDSON, A. V. SINGH, K. J. CHANDLER, D. J. DIX, R. J. KAVLOCK, AND T. B. KNUDSEN. Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 124(1):109-127, (2011).

ROTROFF, D., D. J. DIX, K. A. HOUCK, R. J. KAVLOCK, T. B. KNUDSEN, M. T. MARTIN, D. REIF, A. M. RICHARD, N. SIPES, Y. A. ABASSI, C. JIN, M. STAMPFL, AND R. JUDSON. Real-Time Growth Kinetics Measuring Hormone Mimicry for ToxCast Chemicals in T‑47D Human Ductal Carcinoma Cells . CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 26(7):1097-1107, (2013).

KLEINSTREUER, N., D. J. DIX, M. ROUNTREE, N. BAKER, N. SIPES, D. REIF, R. SPENCER, AND T. B. KNUDSEN. A Computational Model Predicting Disruption of Blood Vessel Development. Shayn M.Pierce (ed.), PLOS Computational Biology. Public Library of Science, San Francisco, CA, 9(4):1-20, (2013).

PADILLA, S. J., D. CORUM, B. K. PADNOS, D. L. HUNTER, A. BEAM, K. A. HOUCK, N. SIPES, N. KLEINSTREUER, T. B. KNUDSEN, D. J. DIX, AND D. M. REIF. Zebrafish Developmental Screening of the ToxCast™ Phase I Chemical Library . REPRODUCTIVE TOXICOLOGY. Elsevier Science Ltd, New York, NY, 33(2):174-187, (2012).

Kavlock, R., K. Chandler, K. Houck, S. Hunter, R. Judson, N. Kleinstreuer, T. Knudsen, M. Martin, S. Padilla, D. Reif, A. Richard, D. Rotroff, N. Sipes, AND D. Dix. Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management. CHEMICAL RESEARCH IN TOXICOLOGY. American Chemical Society, Washington, DC, 25(7):1287-1302, (2012).

DIX, D. J., K. A. HOUCK, R. JUDSON, N. KLEINSTREUER, T. B. KNUDSEN, M. T. MARTIN, D. REIF, A. M. RICHARD, I. A. SHAH, N. SIPES, AND R. J. KAVLOCK. Incorporating Biological, Chemical and Toxicological Knowledge into Predictive Models of Toxicity: Letter to the Editor. TOXICOLOGICAL SCIENCES. Oxford University Press, Cary, NC, 130(2):440-441, (2012).

KLEINSTREUER, N. C., R. S. JUDSON, D. M. REIF, N. S. SIPES, A. V. SINGH, K. J. CHANDLER, R. DEWOSKIN, D. J. DIX, R. J. KAVLOCK, AND T. B. KNUDSEN. Environmental Impact on Vascular Development Predicted by High Throughput Screening. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, 119(11):1596-1603, (2011).

KNUDSEN, T. B., K. A. HOUCK, N. SIPES, A. V. SINGH, R. JUDSON, M. T. MARTIN, A. WEISSMAN, N. KLEINSTREUER, H. M. MORTENSEN, D. REIF, J. R. RABINOWITZ, R. W. SETZER, A. M. RICHARD, D. J. DIX, AND R. J. KAVLOCK. Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets. TOXICOLOGY. Elsevier Ireland Limited, Limerick, Ireland, 282(1-2):1-15, (2011).

CHANDLER, K. J., M. BARRIER, S. C. JEFFAY, H. P. NICHOLS, N. KLEINSTREUER, A. Singh, D. REIF, N. SIPES, R. JUDSON, D. J. DIX, R. J. KAVLOCK, E. S. HUNTER, AND T. Knudsen. Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. PLOS ONE . Public Library of Science, San Francisco, CA, 6(6):e1840, (2011).

SIPES, N. S., S. J. PADILLA, AND T. B. KNUDSEN. Zebrafish – As an Integrative Model for Twenty-first Century Toxicity Testing. Birth Defects Research, Part C: Embryo Today: Reviews. Wiley Liss, New York, NY, 93(3):256-267, (2011).