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Records 1 to 22 of 22
Application of Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling in Cumulative Risk Assessment for N-Methyl Carbamate Insecticides
Human exposure to xenobiotics may occur through multiple pathways and routes of entry punctuated by exposure intervals throughout a work or leisure day. Exposure to a single environmental chemical along multiple pathways and routes (aggregate exposure) may have an influence on an...
COMPUTATIONAL ENVIRONMENTAL TOXICOLOGY
A book chapter that describes the applications of computational toxicology.
Can Chemicals in the Environment That Affect Hormone Function Disrupt Development?
Hormones, including estrogens and androgens, regulate the expression of genes that play critical roles in guiding the development of organ systems in the embryo. Changes in either the amount or the timing of hormone exposure can lead to altered human development. For example, hum...
Can Computational Models Be Used to Assess the Developmental Toxicity of Environmental Exposures?
Environmental causes of birth defects include maternal exposure to drugs, chemicals, or physical agents. Environmental factors account for an estimated 3–7% of birth defects although a broader contribution is likely based on the mother’s general health status and genetic blueprin...
Comparative BioInformatics and Computational Toxicology
Reflecting the numerous changes in the field since the publication of the previous edition, this third edition of Developmental Toxicology focuses on the mechanisms of developmental toxicity and incorporates current technologies for testing in the risk assessment process.
Computational Approaches for Developing Informative Prior Distributions for Bayesian Calibration of PBPK Models (Book Chapter)
Using Bayesian statistical methods to quantify uncertainty and variability in human physiologically-based pharmacokinetic (PBPK) model predictions for use in risk assessments requires prior distributions (priors), which characterize what is known or believed about parameters’ val...
Computational Toxicology
‘Computational toxicology’ is a broad term that encompasses all manner of computer-facilitated informatics, data-mining, and modeling endeavors in relation to toxicology, including exposure modeling, physiologically based pharmacokinetic (PBPK) modeling, dose-response modeling, ...
Computational Toxicology in Cancer Risk Assessment
Risk assessment over the last half century has, for many individual cases served us well, but has proceeded on an extremely slow pace and has left us with considerable uncertainty. There are certainly thousands of compounds and thousands of exposure scenarios that remain unteste...
Differential Toxicity Characterization of Green Alternative Chemicals
Assessing the toxicity of a chemical across all possible disease domains and understanding its dose- response behavior cost millions to tens of millions of dollars per chemical, and can take years to decades to evaluate fully. This expense and the lack of regulatory requirements ...
Fundamental concepts, current regulatory design and interpretation
Developmental toxicology became a formalized field about 50 years ago. Over this time, it has evolved from a largely observational science to one that is highly mechanistic in nature. Our increasing knowledge of mechanism of action, coupled with techniques that facilitate the gen...
How Can We Use Bioinformatics to Predict Which Agents Will Cause Birth Defects?
The availability of genomic sequences from a growing number of human and model organisms has provided an explosion of data, information, and knowledge regarding biological systems and disease processes. High-throughput technologies such as DNA and protein microarray biochips are ...
Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) Assay: Book Chapter
There are thousands of environmental chemicals for which there is limited toxicological information, motivating the development and application of in vitro systems to profile the biological effects of xenobiotic exposure and predict their potential developmental hazard. An adher...
Parameters for Pyrethroid Insecticide QSAR and PBPK/PD Models for Human Risk Assessment
This pyrethroid insecticide parameter review is an extension of our interest in developing quantitative structure–activity relationship–physiologically based pharmacokinetic/pharmacodynamic (QSAR-PBPK/PD) models for assessing health risks, which interest started with the organoph...
Pesticides as endocrine-disrupting chemicals
Pesticides are designed to be bioactive against certain targets but can cause toxicity to nontarget species by a variety of other modes of action including disturbance of endocrine function. As such, pesticides have been found to bind and alter the function of hormone receptors, ...
Predictive Modeling and Computational Toxicology
Embryonic development is orchestrated via a complex series of cellular interactions controlling behaviors such as mitosis, migration, differentiation, adhesion, contractility, apoptosis, and extracellular matrix remodeling. Any chemical exposure that perturbs these cellular proce...
Predictive Models and Computational Toxicology
Understanding the potential health risks posed by environmental chemicals is a significant challenge elevated by the large number of diverse chemicals with generally uncharacterized exposures, mechanisms, and toxicities. The ToxCast computational toxicology research program was l...
Systems Modeling in Developmental Toxicity
An individual starts off as a single cell, the progeny of which form complex structures that are themselves integrated into progressively larger systems. Developmental biology is concerned with how this cellular complexity and patterning arises through orchestration of cell divi...
The VIRTUAL EMBRYO. A Computational Framework for Developmental Toxicity
EPA’s ‘Virtual Embryo Project’ (v-Embryo™) is focused on the predictive toxicology of children’s health and developmental defects following prenatal exposure to environmental chemicals. The research is motivated by scientific principles in systems biology as a framework for the g...
ToxCast and Virtual Embryo: in vitro data and in silico models for predictive toxicology
Human populations may be exposed to thousands of chemicals only a fraction of which have detailed toxicity data. Traditional in vivo animal testing is costly, lengthy and normally conducted with dosages that exceed relatively insensitive to concentrations of chemicals at realisti...
ToxCast: PREDICTING TOXICITY POTENTIAL THROUGH HIGH-THROUGHPUT BIOACTIVITY PROFILING
Book Chapter
Toxicogenomics and the Regulatory Framework
Toxicogenomics presents regulatory agencies with the opportunity to revolutionize their analyses by enabling the collection of information on a broader range of responses than currently considered in traditional regulatory decision making. Analyses of genomic responses are expec...
Virtual Tissues and Developmental Systems Biology (book chapter)
Virtual tissue (VT) models provide an in silico environment to simulate cross-scale properties in specific tissues or organs based on knowledge of the underlying biological networks. These integrative models capture the fundamental interactions in a biological system and enable ...


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