Science Inventory

Next >>

BACKGROUND AND AIM: Fine particulate air pollution (PM2.5) exposure is associated with increased risk of hospital readmissions. This study aims to determine if this association differs according to the attributable source of the PM2.5. METHODS: We used zero-inflated poisson mix...

Background: As the global population ages, decreased lung function and lung disease will continue to be significant contributors to morbidity and mortality. Molecular changes associated with age have been implicated in the pathogenesis of lung disease and decreased lung function....

Background: Environmental exposures (both social and chemical) are some of the most important determinants of health and wellness. Despite decades of air quality improvements, air pollution exposure remains one of the most significant contributors to morbidity and mortality in th...

Background Heart failure (HF) is a severe form of cardiovascular disease which is increasing in prevalence. While the mortality risks from elevlated ambient fine particulate matter (PM2.5) exposure are well characaterized for HF patients, few studies have examined morbidity risks...

This presentation, "Wildfire Advancing Science Partnerships for Indoor Reduction of Smoke Exposures (ASPIRE) Study," provides an overview of the methods, results and significance of the Wildfire ASPIRE Study components, including the 2019 web summit on clean air spaces;...

The changing intensity, and scale of wildfire is a symptom of climate change with significant smoke-related impacts on public health and downwind ecosystems.  On-going climate change will continue altering these patterns while at the same time affecting the variables that de...

Poster describing our recent results using disability adjusted life years (DALYs) to compare the immediate risks from exposure to wastewater treated for non-potable end uses to the health impacts associated with the treatment systems. 

The maintainers of the Environmental Protection Agency's (EPA) Storm Water Management Model (SWMM) at the Office of Research and Development (ORD) and partners are pleased to offer a hands-on workshop focused on the SWMM model at this year's ASCE conference. This full-day worksho...

The United States Environmental Protection Agency’s (EPA) Stormwater Management Model (SWMM) has been an indispensable tool for engineers and researchers for stormwater and wastewater related studies and infrastructure design since its development about 50-years ago. This p...

This presentation gives a high-level overview of the testbed on the Edison Environmental Center 

The biogeochemical processing of nitrogen and associated pollutants is driven by meteorological and hydrological processes in conjunction with pollutant loading. There are feedbacks between meteorology and hydrology that will be affected by land-use change and climate change. Cha...

Onsite wastewater treatment and disposal systems can be a significant source of groundwater pollution. Subsurface transport of excess nutrients and co-pollutants in wastewater effluent (e.g. pathogens, pharmaceuticals, per- and polyfluoroalkyl substances) to drinking water wells ...

Wildfires and the changing landscape of air pollution related health burden  Wildfires are a major sources of air pollution. Understanding emerging patterns of wildfire-related health burden, including identification of the most affected populations, is key to formulating an...

The St. Louis River estuary has been subject to industrial contamination, overfishing and habitat degradation. Due to these factors the estuary has been designated an area of concern and has undergone major remediation and habitat restoration efforts. Lake Sturgeon (Acipenser ful...

Background and Purpose:  Our goal was to evaluate ToxCastTM unique asay gene targets for biological relevancy to neurotoxicity/developmental neurotoxicity, and to compare the results to putative mechanisms of action of previously identified neurotoxicants. Methods:  A p...

SOT 2025 Conference abstract: Proteome profiling of emamectin-treated primary rat cortical cells following up to twelve days in vitro exposure W.M. Winnik, W. Padgett, D. Freeborn,  D.W. Herr, P.R.S. Kodavanti Background and Purpose: In vitro new approach methods (NAMs) have...

Freshwater fish in the United States are at risk from changing stream temperatures and introduced fish, but effects across broad spatial extents remain unclear. We analyzed biodiversity (abundance, richness, uniqueness, functional diversity) of 389 species across 27 years and 299...

Inhalation is one of the three primary modes of chemical exposure, but it is particularly challenging to screen inhalable substances with in vitro methods. Air-liquid interface (ALI) exposure systems allow direct cell-toxicant interactions and can be applied for a broader variety...

New Approach Methods (NAMs) are increasingly used to assess the toxicity of inhalable substances, highlighting the need to optimize exposure techniques for airway cell cultures. While air-liquid interface (ALI) exposure systems preserve the physicochemical properties of inhalable...

Though estrogenic and androgenic contaminants have received extensive attention as endocrine disrupting and modulating chemicals causing water quality concerns, glucocorticoid agonism has been receiving increasing attention in aquatic systems. Of particular interest are synthetic...

New Approach Methodologies (NAMs) are being developed to foster efficient screening for neurotoxicity (NT), and reliability in these methods for regulatory purposes is necessary, entailing in vivo assessments for corroboration. We have shown alignment of NAMs with terms in NT Adv...

Wildfire smoke changes with combustion conditions and fuel types, however the specific role of wildfire conditions on health effects are uncertain. This study applied a novel combustion and smoke-collection system to examine emissions from multiple biomass fuel types (oak, peat, ...

Background and Purpose:   Humans are exposed to thousands of chemicals throughout their lifetime, yet more than 100,000 of these compounds remain untested for their potential neurotoxic effects.  The National Academy of Science has suggested utilizing advances in m...

Background: Exposure to airborne fine particulate matter (PM2.5) is a leading cause of morbidity and mortality worldwide. Exposure to PM2.5 is associated with a wide range of adverse outcomes such as exacerbation of cardiovascular disease, respiratory infections, and premature de...

  Background and Purpose: As global warming has accelerated in recent years; adverse human health consequences of high external temperature (T) have become a pressing issue. Birds and mammals have evolved to maintain core body T above that of the atmosphere. Increases in amb...