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Reconstructing Population Exposures from Dose Biomarkers: Inhalation of Trichloroethylene (Tce) as a Case Study

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Abstract:Physiologically based pharmacokinetic (PBPK) modeling is a well-established toxicological tool designed to relate exposure to a target tissue dose. The emergence of federal and state programs for environmental health tracking and the availability of exposure monitoring through biomarkers creates the opportunity to apply PBPK models to estimate exposures to environmental contaminants from urine, blood, and tissue samples. However, reconstructing exposures for large populations is complicated by often having too few biomarker samples, large uncertainties about exposures, and large interindividual variability. In this paper, we use an illustrative case study to identify some of these difficulties and for a process for confronting them by reconstructing population-scale exposures using Bayesian inference. The application consists of interpreting biomarker data from eight adult males with controlled chamber. We successfully reconstructed the exposure scenarios for both subgroups although the reconstruction of one subgroup is different than what is believed to be the true experimental conditions. We were however unable to predict with high certainty the concentration of TCE in air.

This work was supported in part by the US Environmental Protection Agency National Exposure Research Laboratory through Interagency Agreement #DW-988-38190-01-0 and carried out at Lawrence Berkley National Laboratory through the US Department of Energy under contract Grant No. DE-AC03-76SF00098. This work is also supported in part by the Health Tracking Center of Excellence at the University of California Berkley, and funded by interagency agreement No. U50CCUT922409-01 with US Centers for Disease Control.
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Citation:Sohn, M. D., T. E. Mckone, and J. N. Blancato. Reconstructing Population Exposures from Dose Biomarkers: Inhalation of Trichloroethylene (Tce) as a Case Study. JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY 14(3):204-213, (2004).
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Exposure & Dose Research Branch
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Product Type: Journal
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Published: 04/14/2004
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Bullet Item Reconstructing Population Exposures from Dose Biomarkers: Inhalation of Trichloroethylene (Tce) as a Case Study
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Related Entries:
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Bullet Item Models and Modeling Methods for Assessing Human Exposure and Dose to Toxic Chemicals and Pollutants
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Last Updated on Monday, October 22, 2007
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