Skip common site navigation and headers
United States Environmental Protection Agency
Exposure Research
Begin Hierarchical Links EPA Home > Research & Development > Exposure Research > Publications/Presentations > End Hierarchical Links

 

Monitoring the Air for Toxic and Genotoxic Compounds

spacer
spacer
Abstract:A time-integrated sampling system interfaced with a toxicity-based assay is reported for monitoring volatile toxic industrial chemicals (TICs). Semipermeable membrane devices (SPMDs) using dimethyl sulfoxide (DMSO) as the fill solvent accumulated each of 17 TICs from the vapor phase. Uptake kinetics experiments for one of these compounds (acrolein) indicated that it was significantly sequestered (i.e., 10 percent of the 24 hr maximum) in as little as 10 min and was concentrated by a factor of over 200 in 24 hr as measured using both mass and toxicity assays. The effect of each of the TICs on the Microtox bacterial luminescence assay was determined both from a direct assay and a vapor accumulation assay using SPMDs. The response of the IQ-tox assay based on Daphnia magna was also investigated for the 17 TICs. EC50 values (i.e., concentration yielding 50% inhibition of measured response) were similar to those observed for the Mocrotox assay.

Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy.
spacer
Citation:Rogers, K. R. Monitoring the Air for Toxic and Genotoxic Compounds. Presented at Green Chemistry Gordon Conference, Bristol, RI, July 4-9, 2004.
spacer
spacer
Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
spacer
Division: Human Exposure & Atmospheric Sciences Division
spacer
Branch: Exposure & Dose Research Branch
spacer
Product Type: Abstrct/Oral
spacer
Presented: 07/07/2004
spacer
Related Entries:
spacer
Bullet Item Biosensors Research for Development of Innovative Monitoring Techniques That Support Exposure Assessment Related to the Superfund Program
spacer Relationship Reason:   A Project of the Product
spacer
spacer
spacer

 

ORD Home | Search EPA | Search NERL | Search EIMS | Contacts | Help

 
Begin Site Footer

EPA Home | Privacy and Security Notice | Contact Us

Last Updated on Monday, October 22, 2007
URL: http://cfpub.epa.gov