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The Unique Value of Breath Biomarkers for Estimating Phamacokinetic Rate Constants and Body Burden from Random/Intermittent Dose

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Abstract:Biomarker measurements are used in three ways: 1) evaluating the time course and distribution of a chemical in the body, 2) estimating previous exposure or dose, and 3) assessing disease state. Blood and urine measurements are the primary methods employed. Of late, it has been recognized that collecting exhaled breath is an attractive alternative to blood and urine sampling because it is less invasive, and is not restricted by sample volume or time frame. Breath volume and frequency of sampling are essentially unlimited; the subject never runs out sample and one can collect even adjacent breaths with existing technology. Furthermore, there is a fundamental difference between blood and breath measurement in that blood levels report only the status quo at the time of collection, whereas exhaled breath is reflective of current blood levels as well as an elimination mechanism allowing calculation of real time removal rates. Therefore, from a mathematical standpoint, the time courses of blood and breath are interpreted differently and give complementary information.

Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy.
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Citation:Pleil, J. D., and D. Kim. The Unique Value of Breath Biomarkers for Estimating Phamacokinetic Rate Constants and Body Burden from Random/Intermittent Dose. Presented at Breath Gas Analysis for Medical Diagnostics, Dornbirn, Austria, September 23-26, 2004.
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Methods Development & Application Branch
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Product Type: Abstrct/Oral
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Presented: 09/25/2004
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Related Entries:
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Bullet Item Xenobiotic Methods Development for Human Exposure Assessment Research
spacer Relationship Reason:   A Project of the Product
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Last Updated on Monday, October 22, 2007
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