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Exhaled Breath Analysis for Human Exposure Research

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Abstract: Exhaled breath collection and analysis has historically been used in environmental research studies to characterize exposures to volatile organic compounds. The use of this approach is based on the fact that many compounds present in blood are reflected in the breath, and that unlike blood, breath collection is noninvasive and generally well tolerated by study subjects. This research has focused on demonstrating exposures to volatile compounds, establishing conclusive links between specific activities and corresponding body burdens of xenobiotics, characterizing uptake and elimination kinetics, and illuminating relevant pathways of exposure. In the past few years exhaled breath analysis has evolved to the point where it is now being used to help characterize biological responses associated with exposures to environmental pollutants.

This presentation will explore historical and newly emerging methods for the collection and analysis of exhaled breath for use in environmental exposure assessment studies. We will discuss their applicability and limitations with respect to environmental research. Particular emphasis will be placed on new methods and their utility for examining exhaled biomarkers of environmental pollution.

Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy.
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Citation:Lindstrom, A. B. Exhaled Breath Analysis for Human Exposure Research. Presented at Conference Breath Gas Analysis in Medical Diagnostics, Dornbirn, Austria, September 23-26, 2004.
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Methods Development & Application Branch
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Product Type: Abstrct/Oral
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Presented: 09/25/2004
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Related Entries:
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Bullet Item Xenobiotic Methods Development for Human Exposure Assessment Research
spacer Relationship Reason:   A Project of the Product
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Last Updated on Monday, October 22, 2007
URL: http://cfpub.epa.gov