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Harmonization and Communication of PBPK Models Using the Exposure Related Dose Estimation Model (Erdem) System: Trichloroethylene

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Abstract:In support of the trichloroethylene (TCE) risk assessment for the Office of Air and Radiation, Office of Solid Waste and Emergency Response, and Office of Water, NERL and NCEA are developing an updated physiologically-based pharmacokinetic (PBPK) model. The PBPK modeling effort is being coordinated with a workgroup co-sponsored by EPA and the U.S. Air Force and facilitated by Toxicology Excellence for Risk Assessment (TERA). The workgroup includes researchers from EPA, academia, the Air Force, and private consulting. PBPK models are powerful computational tools that can be used to link exposure to the internal concentrations of parent compounds and/or active metabolites at the target site(s) of toxicity. Challenges in model development are the comparison and harmonization of existing models, management of multiple diverse datasets, and characterization of the uncertainties. The implementation and documentation of a mathematical model in a general structure addresses these issues by managing the chemicals, compartments, and parameters in a consistent manner. The Exposure Related Dose Estimating Model (ERDEM) platform, developed by NERL, provides an appropriate structure. The EPA Science Advisory Board has stressed the importance of transparency in the updated assessment of TCE. The development of the updated PBPK model in the ERDEM system addresses this charge through its graphical user interface (GUI), standard report generation, and availability to the public. Evaluation of the model can be done at a high level - standard reports or simulations of new scenarios through the GUI - and at varying levels of detail down to the actual FORTRAN code. This enables use and review by researchers of diverse backgrounds.

Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy.
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Citation:Okino, M. S., F. W. Power, J. Blancato, W. Chiu, C. W. Chen, and J. Lipscomb. Harmonization and Communication of PBPK Models Using the Exposure Related Dose Estimation Model (Erdem) System: Trichloroethylene. Presented at EPA Science Forum 2004, Washington, DC, June 1-3, 2004.
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Exposure & Dose Research Branch
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Product Type: Abstrct/Oral
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Presented: 06/02/2004
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Related Entries:
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Bullet Item Models and Modeling Methods for Assessing Human Exposure and Dose to Toxic Chemicals and Pollutants
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