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Comprehensive PBPK Modeling Approach Using the Exposure Related Dose Estimating Model (Erdem)

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Abstract:ERDEM, a complex PBPK modeling system, is the result of the implementation of a comprehensive PBPK modeling approach. ERDEM provides a scalable and user-friendly environment that enables researchers to focus on data input values rather than writing program code. It efficiently manages these inputs and provides reporting and model output assessment capabilities. This simplifies the modeling efforts for toxicologists, risk assessors, exposure scientists and managers. As PBPK models grow in complexity, the implementation of models, preparation and maintenance of inputs, and the assessment of model output results has become more tedious and error prone.

Concern with the management of these diverse tasks, a comprehensive modeling approach was developed which has been integrated into ERDEM and other PBPK modeling projects. The goal of this modeling approach is to improve the modeling process from planning to application for multimedia exposure assessments. The core activities for this approach include identification and implementation of the model design and performance criteria, metabolism structure and parameterization, the model hardware/software specifications, and the model testing and evaluation.

As a comprehensive modeling system, ERDEM contains a PBPK model engine component that can create scenario-based simulations and target dose estimates in multiple compartments for exposure of a species to multiple chemicals and metabolites. The input management component uses a Windows based graphical user interface and relational database, enabling the user to enter, edit, report, and export data sets of user assigned physiological information. The stochastic component evaluates the uncertainty associated with input parameters and model results. ERDEM replaces the traditional program-oriented modeling approach, which is error prone, with a sophisticated and user-friendly model simulation and data management system.

Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy.
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Citation:Ruiz, A., A. Tsang, F. W. Power, J. Licitra, J. N. Blancato, C. C. Dary, and M. V. Evans. Comprehensive PBPK Modeling Approach Using the Exposure Related Dose Estimating Model (Erdem). Presented at Society of Toxicology, Baltimore, MD, March 21-25, 2004.
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Exposure & Dose Research Branch
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Product Type: Abstrct/Oral
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Presented: 03/23/2004
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Related Entries:
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Bullet Item Models and Modeling Methods for Assessing Human Exposure and Dose to Toxic Chemicals and Pollutants
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