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Identifying Compounds Despite Chromatography Limitations: Organophosphates in Treated Sewage

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Abstract:Highly concentrated extracts of sewage treatment plant (STP) effluents contain detectable
levels of dozens of compounds resulting from human activities. Recent concern over use and
disposal of Pharmaceuticals and Personal Care Products (PPCPS) (1) has stimulated interest in
detecting, identifying, and quantifying these and related compounds, in determining their
toxicities, and in assessing the risks they pose to ecosystems and to humans. For any compounds posing such risks, their sources, degradation rates, and degradation products must also be investigated before remediation strategies are developed Gas chromatographic separation in time coupled to mass spectrometric selection by mass (GC/MS) provides the most effective analytical method for identifying trace and ultra-trace levels of analytes in complex extracts that elute or coelute from a GC column, When coelution occurs, MS provides distinct patterns of ion abundances from each compound, which can be correlated with the individual compounds. By contrast, FTIR and NMR require larger amounts than MS of well-separated compounds for analyses. Rather than devise techniques to isolate and concentrate coeluting compounds prior to analysis by other analytical techniques, we have developed a high resolution mass spectrometric technique to identify compounds in complex environmental extracts based on GC/MS data alone.
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Citation:Grange, A. H., L. I. Osemwengie, and G. W. Sovocool. Identifying Compounds Despite Chromatography Limitations: Organophosphates in Treated Sewage. LIQUID CHROMATOGRAPHY/GAS CHROMATOGRAPHY 21(11):1062-1076, (2003).
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Contact: Chris Siebert - (702) 798-2234 or siebert.christopher@epa.gov
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Division: Environmental Sciences Division
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Branch: Environmental Chemistry Branch
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Product Type: Journal
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Published: 11/10/2003
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Related Entries:
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Bullet Item Advances in Sampling, Separation, Detection and Identification That Address Unmet Needs of Oswer and the Regions
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Last Updated on Monday, October 22, 2007
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