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Volatile Organic Compounds as Exposure Biomarkers

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Abstract: Alveolar breath sampling and analysis can be extremely useful in exposure assessment studies involving volatile organic compounds (VOCs). Over recent years scientists from the US Environmental Protection Agency's National Exposure Research Laboratory have developed and refined an alveolar breath collection and analysis technique called the Single Breath Canister (SBC) method which has been applied in a wide range of investigations. This review covers the development of this breath collection technique in the laboratory and the application of this methodology in a range of field studies. Together these studies show how exhaled breath analysis can be used to clearly demonstrate recent exposures to VOCs, to determine compound-specific uptake and elimination kinetics, and to assess the relative importance of various exposure routes (i.e., dermal, ingestion, inhalation) in multipathway scenarios. Specific investigations covered in this overview include: an assessment of exposures related to the residential use of contaminated groundwater; exposures to gasoline and fuel additives at self-service gas stations; swimmers' exposures to trihalomethanes; and occupational exposures to jet fuel vapors.

This work has been funded wholly by the United States Environmental Protection Agency. It has been subjected to Agency review and approved for publication.
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Citation:Lindstrom, A. B., and J. D. Pleil. Volatile Organic Compounds as Exposure Biomarkers.N. Marczin & M.H. Yacoub (ed.), Disease Markers in Exhaled Breath, First Edition. IOS Press, Amsterdam, 346, (2002).
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Exposure Methods & Monitoring Branch
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Product Type: Book Chaptr
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Published: 09/25/2002
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Related Entries:
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Bullet Item Xenobiotic Methods Development for Human Exposure Assessment Research
spacer Relationship Reason:   A Project of the Product
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Last Updated on Monday, October 22, 2007
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