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A Review of the US EPA's Single Breath Canister (Sbc) Method for Exhaled Volatile Organic Biomarkers

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Abstract: Exhaled alveolar breath can provide a great deal of information about an individual?s health and previous exposure to potentially harmful xenobiotic materials. Because breath can be obtained noninvasively and its constituents directly reflect concentrations in the blood, its use has wide potential application in the field of biomarker research. This paper reviews the utility and application of the single breath canister (SBC) method of alveolar breath collection and analysis first developed by the US Environmental Protection Agency (USEPA) in the 1990s. This review covers the development of the SBC technique in the laboratory and its application in a range of field studies. Together these studies specifically show how the SBC method (and exhaled breath analysis in general) can be used to clearly demonstrate recent exposures to volatile organic compounds (VOCs), to link particular activities to specific exposures, to determine compound-specific uptake and elimination kinetics, and to assess the relative importance of various routes of exposure (i.e. dermal, ingestion, inhalation) in multipathway scenarios. Specific investigations covered in this overview include an assessment of exposures related to the residential use of contaminated groundwater, exposures to gasoline and fuel additives at self-service gas stations, swimmers' exposures to trihalomethanes, and occupational exposures to jet fuel.

The US Environmental Protection Agency through its Office of Research and Development wholly funded and managed the research described here. It has been subjected to Agency review and approved for publication. Mention of trade names or commercial products does not constitute an endorsement or recommendation for use.
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Citation:Lindstrom, A. B., and J. D. Pleil. A Review of the US EPA's Single Breath Canister (Sbc) Method for Exhaled Volatile Organic Biomarkers. BIOMARKERS 7(3):189-208, (2002).
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Contact: Liz Hope - (919) 541-2785 or hope.elizabeth@epa.gov
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Division: Human Exposure & Atmospheric Sciences Division
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Branch: Exposure Methods & Monitoring Branch
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Product Type: Journal
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Published: 05/01/2002
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Related Entries:
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Bullet Item Xenobiotic Methods Development for Human Exposure Assessment Research
spacer Relationship Reason:   A Project of the Product
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Last Updated on Monday, October 22, 2007
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